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2999742-92-4

2999742-92-4 Structure

2999742-92-4 Structure
IdentificationBack Directory
[Name]

CBP/p300-IN-20
[CAS]

2999742-92-4
[Synonyms]

CBP/p300-IN-20
[Molecular Formula]

C22H19ClF3N5O2
[MOL File]

2999742-92-4.mol
[Molecular Weight]

477.87
Chemical PropertiesBack Directory
[Boiling point ]

745.4±60.0 °C(predicted)
[density ]

1.54±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[form ]

Solid
[pka]

10.48±0.40(predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

CBP/p300-IN-20 is a potent and selective p300/CBP inhibitor, with a pIC50 of 10.1 for p300. CBP/p300-IN-20 can be used for the research of cancer[1].
[in vivo]

CBP/p300-IN-20 (compound 28) (0.54 mg/kg; i.v.) exhibits Cmax (210 ng/mL), AUC0→∞ (102 h?ng/mL), CL (95 mL/min/kg), and T1/2 (0.3 h) in rats[1].

[IC 50]

CBP/p300: 10.1 (pIC50)
[References]

[1] Tian X, et, al. Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening. J Med Chem. 2022 Nov 10;65(21):14391-14408. DOI:10.1021/acs.jmedchem.2c00670
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