| Identification | Back Directory | [Name]
Benzeneacetamide, α-[[(2R)-2-(4-cyanophenyl)propyl]amino]-N-[5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]-, (αR)- | [CAS]
2374972-35-5 | [Synonyms]
Benzeneacetamide, α-[[(2R)-2-(4-cyanophenyl)propyl]amino]-N-[5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]-, (αR)- | [Molecular Formula]
C27H26N6O | [MOL File]
2374972-35-5.mol | [Molecular Weight]
450.53 |
| Chemical Properties | Back Directory | [Boiling point ]
719.1±60.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
12.12±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
(R,R)-CPI-1612 is the isomer of CPI-1612 (HY-136285), and can be used as an experimental control. CPI-1612 is a highly potent, orally active EP300/CBP histone acetyltransferase (HAT) inhibitor with an IC50 of 8.1 nM for EP300 HAT. CPI-1612 has an anticancer activity[1]. | [References]
[1] Jonathan E Wilson, et al. Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor. ACS Med Chem Lett. 2020 Apr 23;11(6):1324-1329. DOI:10.1021/acsmedchemlett.0c00155 |
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