| Identification | Back Directory | [Name]
Androstane-3,11-dione-16,16,17-d3, 17-hydroxy-, (5α,17β)- | [CAS]
2479914-02-6 | [Synonyms]
Androstane-3,11-dione-16,16,17-d3, 17-hydroxy-, (5α,17β)- | [Molecular Formula]
C19H28O3 | [MOL File]
2479914-02-6.mol | [Molecular Weight]
304.43 |
| Chemical Properties | Back Directory | [solubility ]
DMF: 20 mg/ml
DMSO: 30 mg/ml
DMSO: PBS (pH 7.2) (1:10): 0.09 mg/ml
Ethanol: 20 mg/ml | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
11-Ketodihydrotestosterone-d3 is the deuterium labeled 11-Ketodihydrotestosterone. 11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone is an active androgen and is also a potent androgen receptor (AR) agonist with a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostate cancer cells[1][2]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Pretorius E, et al. 1-Ketotestosterone and 11-Ketodihydrotestosterone in Castration Resistant Prostate Cancer: Potent Androgens Which Can No Longer Be Ignored. PLoS One. 2016 Jul 21;11(7):e0159867. DOI:10.1371/journal.pone.0159867
[3] du Toit T, et al. Profiling adrenal 11β-hydroxyandrostenedione metabolites in prostate cancer cells, tissue and plasma: UPC2-MS/MS quantification of 11β-hydroxytestosterone, 11keto-testosterone and 11keto-dihydrotestosterone. J Steroid Biochem Mol Biol. 2017 Feb;166:54-67. DOI:10.1016/j.jsbmb.2016.06.009 |
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