| Identification | Back Directory | [Name]
Clathrin-IN-2 | [CAS]
2650733-69-8 | [Synonyms]
Clathrin-IN-2
9H-Carbazole-9-ethanol, 3,6-dibromo-α-[(dimethylamino)methyl]-, (αS)- | [Molecular Formula]
C17H18Br2N2O | [MOL File]
2650733-69-8.mol | [Molecular Weight]
426.15 |
| Hazard Information | Back Directory | [Uses]
Clathrin-IN-2 is potent inhibitor of clathrin mediated endocytosis (CME) with an IC50 value of 2.3 μM. Clathrin-IN-2 also has inhibitiory for dyn I GTPase with an IC50 value of 7.7 μM[1]. | [References]
[1] Peter J Cossar, et al. Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. Eur J Med Chem. 2022 Dec 15;247:115001. DOI:10.1016/j.ejmech.2022.115001 |
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