| Identification | Back Directory | [Name]
Clathrin-IN-4 | [CAS]
762242-59-1 | [Synonyms]
Clathrin-IN-4
9H-Carbazole-9-ethanol, 3,6-dibromo-α-[(dimethylamino)methyl]-, (αR)- | [Molecular Formula]
C17H18Br2N2O | [MOL File]
762242-59-1.mol | [Molecular Weight]
426.15 |
| Chemical Properties | Back Directory | [Boiling point ]
320.2±22.0 °C(Predicted) | [density ]
1.62±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
14.40±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Clathrin-IN-4 (compound 8b), a Wiskostatin (HY-12534) analogue, is a potent inhibitor of clathrin mediated endocytosis with an IC50 of 2.1 μM. Clathrin-IN-4 is a dynamin I GTPase activity inhibitor with an IC50 of 9.1 μM[1]. | [References]
[1] Peter J Cossar, et al. Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. Eur J Med Chem. 2022 Dec 15;247:115001. DOI:10.1016/j.ejmech.2022.115001 |
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