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2761146-51-2

2761146-51-2 Structure

2761146-51-2 Structure
IdentificationBack Directory
[Name]

5-Quinolinecarboxamide, N-(1-methylethyl)-2-(5,6,7-trifluoro-1H-indol-3-yl)-
[CAS]

2761146-51-2
[Synonyms]

VPC-13789
5-Quinolinecarboxamide, N-(1-methylethyl)-2-(5,6,7-trifluoro-1H-indol-3-yl)-
[Molecular Formula]

C21H16F3N3O
[MOL File]

2761146-51-2.mol
[Molecular Weight]

383.37
Chemical PropertiesBack Directory
[Boiling point ]

640.9±55.0 °C(Predicted)
[density ]

1.364±0.06 g/cm3(Predicted)
[pka]

12.63±0.30(Predicted)
Hazard InformationBack Directory
[Uses]

VPC-13789 is a potent, selective, and orally bioavailable antiandrogen. VPC-13789 can be used for the research of castration-resistant prostate cancer (CRPC) therapeutics. VPC-13789 inhibits androgen receptor (AR) transcriptional activity in LNCaP cells (IC50=0.19 μM)[1].
[References]

[1] Eric Leblanc , et al. Development of 2-(5,6,7-Trifluoro-1 H-Indol-3-yl)-quinoline-5-carboxamide as a Potent, Selective, and Orally Available Inhibitor of Human Androgen Receptor Targeting Its Binding Function-3 for the Treatment of Castration-Resistant Pr DOI:10.1021/acs.jmedchem.1c00681
2761146-51-2 suppliers list
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Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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