| Identification | Back Directory | [Name]
Methanone, [4-[[5-chloro-4-(5-chloro-2-thienyl)-2-pyrimidinyl]amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]- | [CAS]
2797225-47-7 | [Synonyms]
PfGSK3/PfPK6-IN-2
Methanone, [4-[[5-chloro-4-(5-chloro-2-thienyl)-2-pyrimidinyl]amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]- | [Molecular Formula]
C24H25Cl2N5OS | [MOL File]
2797225-47-7.mol | [Molecular Weight]
502.46 |
| Hazard Information | Back Directory | [Uses]
PfGSK3/PfPK6-IN-2 is a potent dual PfGSK3/PfPK6 (Plasmodium falciparum GSK3/PK6) inhibitor (IC50: 172 nM and 11 nM respectively). PfGSK3/PfPK6-IN-2 can be used in the research of Malaria[1]. | [References]
[1] Galal KA, et al. Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial PfGSK3/PfPK6 with Activity against Blood Stage Parasites In Vitro. J Med Chem. 2022 Oct 13;65(19):13172-13197. DOI:10.1021/acs.jmedchem.2c00996 |
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