| Chemical Properties | Back Directory | [Boiling point ]
1045.8±65.0 °C(predicted) | [density ]
1.43±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
10.81±0.40(predicted) | [color ]
Light yellow to green yellow |
| Hazard Information | Back Directory | [Uses]
GBD-9 is a double-mechanism degrader that efficiently degrades BTK and GSPT1 by recruiting the E3 ligase cereblon (CRBN). GBD-9 acts both as a PROTAC molecule to induce the degradation of BTK and as a molecular glue to degrade GSPT1. GBD-9 effectively inhibits cancer cell growth[1]. | [IC 50]
Cereblon | [References]
[1] Zimo Yang, et al. Merging PROTAC and molecular glue for degrading BTK and GSPT1 proteins concurrently. Cell Res. 2021 Dec;31(12):1315-1318. DOI:10.1038/s41422-021-00533-6 |
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