1002309-52-5
1002309-52-5 結(jié)構(gòu)式
基本信息
1-甲基-6-氧代-1,6-二氫吡啶-3-硼酸頻哪醇酯
1-甲基-6-氧代-1,6-二氫吡啶-3-硼酸頻那醇酯
1-甲基-6-氧代-1,6-二氫吡啶-3-基硼酸頻哪醇酯
1-Methyl-6-oxo-1,6-dihydropyridine-3-boronic Acid Pinacol Ester
1-methyl-6-oxo-1,6-dihydropyridin-3-ylboronic acid pinacol ester
1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-one
1-METHYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-2(1H)-PYRIDINONE
1-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one
1-Methyl-5-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1,2-dihydropyridin-2-one
1-METHYL-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-1H-PYRIDIN-2-ONE
2(1H)-PYRIDINONE, 1-METHYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-
1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one 98%
物理化學(xué)性質(zhì)
制備方法
81971-39-3
73183-34-3
1002309-52-5
以5-溴-1-甲基吡啶-2-酮（200.0 mg，1.06 mmol）和雙（頻哪醇合）二硼（410.0 mg，1.61 mmol）為原料，加入乙酸鉀（270 mg，2.67 mmol）和Pd(dppf)Cl2（80 mg，0.11 mmol）的二惡烷（5 mL）溶液。將反應(yīng)混合物在100℃下微波加熱2小時(shí)。反應(yīng)完成后，將混合物過濾，用水洗滌，并用乙酸乙酯（20 mL×3）萃取。合并有機(jī)相，用無水硫酸鈉干燥，過濾后濃縮，得到粗產(chǎn)物1-甲基-6-氧代-1,6-二氫吡啶-3-硼酸頻哪醇酯（59.0 mg，收率23.6%）。產(chǎn)物經(jīng)LCMS檢測，分子離子峰（M + H）+為236。
參考文獻(xiàn)：
[1] Patent: US2015/111885, 2015, A1. Location in patent: Paragraph 0574; 0575
[2] Patent: EP2168965, 2010, A1. Location in patent: Page/Page column 33
[3] Patent: WO2008/8539, 2008, A2. Location in patent: Page/Page column 117-118
[4] Patent: WO2012/3189, 2012, A1. Location in patent: Page/Page column 81
[5] Patent: WO2011/60235, 2011, A1. Location in patent: Page/Page column 22
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/12/22 | XW02100230952506 | 1-甲基-6-氧代-1,6-二氫吡啶-3-硼酸頻那醇酯 | 1002309-52-5 | 25G | 1495元 |
| 2025/12/22 | XW02100230952505 | 1-甲基-6-氧代-1,6-二氫吡啶-3-硼酸頻那醇酯 | 1002309-52-5 | 10G | 792元 |
| 2025/12/22 | XW02100230952504 | 1-甲基-6-氧代-1,6-二氫吡啶-3-硼酸頻那醇酯 | 1002309-52-5 | 5G | 441元 |