1009104-85-1
中文名稱
Smad3 Inhibitor, SIS3
英文名稱
Smad3 Inhibitor, SIS3
CAS
1009104-85-1
分子式
C28H27N3O3
分子量
453.53
MOL 文件
1009104-85-1.mol
更新日期
2023/03/20 15:41:25
1009104-85-1 結(jié)構(gòu)式
基本信息
中文別名
SIS3游離化合物 T12923
(E)-1-(6,7-二甲氧基-3,4-二氫異喹啉-2(1H)-基)-3-(1-甲基-2-苯基-3-吡咯并[2,3-B]吡啶基)-2-丙烯-1-酮
英文別名
SIS3 free baseSmad3 Inhibitor
SMAD3 Inhibtor, SIS 3
Smad3 Inhibitor, SIS3
(E)-1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-3-pyrrolo[2,3-b]pyridyl)-2-propen-1-one
2-Propen-1-one, 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-
物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.2 mg/ml
形態(tài)結(jié)晶固體
顏色off-white
InChI1S/C28H27N3O3/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31/h4-12,14,16-17H,13,15,18H2,1-3H3
InChIKeyIJYPHMXWKKKHGT-UHFFFAOYSA-N
SMILES[n]1(c2ncccc2c(c1c5ccccc5)C=CC(=O)N3CCc4c(cc(c(c4)OC)OC)C3)C
應(yīng)用領(lǐng)域
用途一
SMAD3 Inhibitor, SIS3 selectively inhibits TGF-β and activin. It has been shown to reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.