1032528-06-5
1032528-06-5 結構式
基本信息
(1-(4-(4,4,5,5-四甲基-1,3,2-二氧雜環(huán)戊硼烷-2-基)苯基)環(huán)丁基)氨基甲酸叔丁酯
tert-Butyl (1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)
tert-butyl N-{1-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutyl}carbamate
tert-butyl 1-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbaMate
Tert-butyl N-[1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutyl]carbamate
[1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]cyclobutyl]carbamic acid tert-butyl ester
N-[1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutyl]Carbamic acid 1,1-dimethylethyl ester
CarbaMic acid, N-[1-[4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutyl]-, 1,1-diMethylethyl ester
物理化學性質
制備方法
![[1-(4-溴苯基)環(huán)丁基]氨基甲酸叔丁酯](/CAS/GIF/1032350-06-3.gif)
1032350-06-3
73183-34-3
1032528-06-5
步驟5：在500 mL脫氣的四氫呋喃（THF）中，加入27.75 g（55 mmol）1-(4-溴苯基)環(huán)丁基氨基甲酸叔丁酯、23.76 g（93.6 mmol）聯硼酸頻那醇酯、25 g（255 mmol）乙酸鉀和2.08 g（2.55 mmol）1,1'-雙(二苯基膦基)二茂鐵二氯化鈀(II)。將反應混合物加熱回流3小時，觀察到反應混合物的顏色從深紅色變?yōu)楹谏Ｓ捎诜磻煌耆?，繼續(xù)加熱2小時。反應完成后，將反應混合物倒入400 mL水中，并用700 mL乙酸乙酯稀釋。攪拌30分鐘后，分離有機相，水相分別用400 mL和200 mL乙酸乙酯再萃取兩次。合并有機萃取液，用200 mL鹽水洗滌，并用硫酸鈉干燥。蒸發(fā)溶劑后，通過Biotage色譜法純化殘余物，得到28.99 g（產率91.3%）1-(4-(4,4,5,5-四甲基-1,3,2-二氧硼戊環(huán)-2-基)苯基)環(huán)丁基氨基甲酸叔丁酯。1H NMR（400 MHz, DMSO-d6）δ: 7.51-7.67（m, 3H）, 7.38（d, 2H）, 2.22-2.42（m, 4H）, 1.88-2.02（m, 1H）, 1.63-1.80（m, 1H）, 1.00-1.38（m, 21H）ppm。
參考文獻：
[1] Patent: WO2013/104611, 2013, A1. Location in patent: Page/Page column 48
[2] Patent: WO2012/7416, 2012, A1. Location in patent: Page/Page column 75; 76
[3] Patent: US2014/5185, 2014, A1. Location in patent: Paragraph 0256-0258
[4] Patent: EP2868660, 2015, A1. Location in patent: Paragraph 0172
[5] Patent: WO2012/7345, 2012, A2. Location in patent: Page/Page column 243