1041852-85-0
中文名稱
CS-2850
英文名稱
AZD7507
CAS
1041852-85-0
分子式
C23H27FN6O3
分子量
454.5
MOL 文件
1041852-85-0.mol
更新日期
2026/06/10 11:03:48
1041852-85-0 結(jié)構(gòu)式
基本信息
中文別名
化合物CS-2850 英文別名
AZD7507CS-2850
AZD7507
AZD-7507
AZD 7507
1041852-85-0
4-(2-fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide
3-Cinnolinecarboxamide, 4-[(2-fluoro-4-methylphenyl)amino]-6-[4-(2-hydroxyethyl)-1-piperazinyl]-7-methoxy-
物理化學(xué)性質(zhì)
沸點(diǎn)680.7±65.0 °C(Predicted)
密度1.346±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)14.47±0.30(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
CS-2850價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-117244 | AZD7507 | 1041852-85-0 | 1 mg | 466元 |
| 2026/06/05 | HY-117244 | CS-2850 AZD7507 | 1041852-85-0 | 5mg | 1200元 |
| 2026/06/05 | HY-117244 | CS-2850 AZD7507 | 1041852-85-0 | 10mM * 1mLin DMSO | 1320元 |
常見問題列表
生物活性
AZD7507 為一種有效的、可口服的 CSF-1R 抑制劑，具有抗腫瘤活性。靶點(diǎn)
CSF-1R
體外研究
AZD7507 (Compound 31) inhibits the proliferation of 3T3 cells engineered to express CSF-1R and stimulated with CSF-1 (IC 50 , 32 nM), shows inhibitory activity against hERG and NaV1.5, with IC 50 s of >30 and 26 μM.
體內(nèi)研究
AZD7507 has good rat oral PK, with in vivo clearance of 7 mL/min/kg and 42% bioavailability. In the canine L-type Ca channel assay, the IC 50 is >20 μM. AZD7507 significantly decreases the number of CD68 + macrophages in mice, and also reduces the volume and mass in mice bearing CC-LP-1 and SNU-1079 cells, but not WITT-1 cells.