1049004-32-1
1049004-32-1 結(jié)構(gòu)式
基本信息
4-(乙氧羰基)環(huán)己烯-1-硼酸頻哪醇酯
1-乙氧基羰基環(huán)己-3-烯-4-硼酸頻哪醇酯
ETHYL4-(4,41-乙氧基羰基環(huán)己-3-烯-4-硼酸頻哪醇酯
4-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-3-環(huán)己烯E-1-羧酸乙酯
4-(4,4,5,5-四甲基-[1,3,2]二氧雜硼雜環(huán)戊烷-2-基)環(huán)己-3-烯-1-羧基LIC ACID 乙基 酯
1-Ethoxycarbonylcyclohex-3-ene-4-boronic acid pinacol ester
4-(Ethoxycarbonyl)cyclohexene-1-boronic acid, pinacol ester
4-(ETHOXY(HYDROXY)BORYL)CYCLOHEX-3-ENECARBOXYLATE PINACOL ESTER
4-(Ethoxycarbonyl)cyclohexene-1-boronic acid, pinacol ester 97%
Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cycl...
ethyl 4-(hydroxy((3-hydroxy-2,3-dimethylbutan-2-yl)oxy)boryl)cyclohex-
ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-enecarboxylate
ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-ene-1-carboxylate
Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyclohexene-1-carboxylate
物理化學(xué)性質(zhì)
制備方法
122948-57-6
73183-34-3
1049004-32-1
以4-((三氟甲烷磺酰基)氧基)-3-環(huán)己烯-1-羧酸乙酯（303 mg，1 mmol）和聯(lián)硼酸頻那醇酯（370 mg，1.5 mmol）為原料，加入KOAc（400 mg，4 mmol）和Pd(dppf)Cl2（10 mg，0.05 mmol）于二惡烷（5 mL）中。將反應(yīng)混合物在110℃下加熱16小時。反應(yīng)完成后，冷卻至室溫，將混合物在EtOAc（10 mL）和飽和NaHCO3溶液（10 mL）之間分配。水相用EtOAc（10 mL × 2）萃取。合并的有機(jī)相用鹽水洗滌，經(jīng)無水MgSO4干燥，過濾，濃縮。通過快速色譜法（25% EtOAc的石油醚溶液）純化，得到4-硼酸頻哪醇酯-3-環(huán)己烯甲酸乙酯（250 mg，收率89%）。LRMS m/z (M + H)+: 281（實(shí)測值），281（計算值）。
參考文獻(xiàn)：
[1] Patent: WO2014/81619, 2014, A1. Location in patent: Page/Page column 128
[2] Patent: US2011/251183, 2011, A1. Location in patent: Page/Page column 18
[3] Patent: US2011/263578, 2011, A1. Location in patent: Page/Page column 34
[4] Patent: WO2011/128265, 2011, A1. Location in patent: Page/Page column 34
[5] Patent: US2011/275801, 2011, A1. Location in patent: Page/Page column 49