106577-39-3
中文名稱
黑海常春藤苷A1
英文名稱
Hederacolchiside A1
CAS
106577-39-3
分子式
C47H76O16
分子量
897.1
MOL 文件
106577-39-3.mol
更新日期
2024/12/26 13:55:57
106577-39-3 結(jié)構(gòu)式
基本信息
中文別名
黑海常春藤苷A1黑海常春藤皂苷A1
竹節(jié)香附皂苷R13
革葉常春藤皂苷A1
HEDERACOLCHISIDE A1(標(biāo)準(zhǔn)品)
齊墩果酸-3-O-Α-L鼠李吡喃糖基-(1→2)[Β-D-葡萄吡喃糖基-(1→4)] -Α-L-吡喃阿拉伯糖苷
齊墩果酸-3-O-Β-D-吡喃鼠李糖基-(1→2)-[Β-D-吡喃葡萄糖基-(1→4)]-Α-L-吡喃阿拉伯糖苷
英文別名
Raddeanoside R13Hederacolchiside A1
HEDERACOLCHISIDE A1
Hederacolchiside A1 USP/EP/BP
Oleanolic acid-3-O-β-D-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)-]-α-L-arabinopyranoside，Hederacolchiside A1
Olean-12-en-28-oicacid, 3-[(O-6-deoxy-a-L-mannopyranosyl-(12)-O-[b-D-glucopyranosyl-(14)]-a-L-arabinopyranosyl)oxy]-, (3b)-
Olean-12-en-28-oic acid, 3-[(O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosyl)oxy]-, (3β)-
所屬類別
生物化工：植物提取物物理化學(xué)性質(zhì)
熔點(diǎn)253-255℃ (methanol , water )
沸點(diǎn)967.2±65.0 °C(Predicted)
密度1.36±0.1 g/cm3 (20 ºC 760 Torr)
儲(chǔ)存條件4°C, protect from light
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)4?+-.0.70(Predicted)
形態(tài)Solid
顏色White to off-white
化妝品成分功效SKIN CONDITIONING
黑海常春藤苷A1價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-N6950 | 黑海常春藤苷A1 Hederacolchiside A1 | 106577-39-3 | 1 mg | 500元 |
| 2026/06/05 | HY-N6950 | 黑海常春藤苷A1 Hederacolchiside A1 | 106577-39-3 | 5mg | 1500元 |
| 2026/06/05 | HY-N6950 | 黑海常春藤苷A1 Hederacolchiside A1 | 106577-39-3 | 10mg | 2200元 |
常見問(wèn)題列表
生物活性
Hederacolchiside A1 是從白頭翁中分離的，通過(guò)調(diào)節(jié) PI3K/Akt/mTOR 信號(hào)通路誘導(dǎo)凋亡，從而抑制腫瘤細(xì)胞的增殖。Hederacolchiside A1 具有抗血吸蟲病活性，影響體內(nèi)和體外的寄生蟲生存力。靶點(diǎn)
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PI3K
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Akt
|
mTOR
|
體外研究
Hederacolchiside A1 reduces the mitochondrial membrane potential and Bcl-2 protein levels, whereas cleaved caspase-3 was higher.
Hederacolchiside A1 effectively inhibits the phosphorylations of phosphatidylinositol 3 kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) .
體內(nèi)研究
hederacolchiside A1 (3.0, 4.5, and 6.0?mg/kg, ip) can significantly inhibit the weight of tumor in an H22 xenograft model.
Hederacolchiside A1 (3.25, 7.5, and 15.0?mg/kg, ig) can significantly inhibit the weight of tumor in nude mice xenograft tumor models using human breast carcinoma MCF-7 cells.