107220-29-1
中文名稱
反式西維美林鹽酸鹽
英文名稱
trans-Cevimeline Hydrochloride
CAS
107220-29-1
分子式
C10H18ClNOS
分子量
235.774
MOL 文件
107220-29-1.mol
107220-29-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 T29681TRANS-CEVIMELINE HCL
英文別名
AF 102A HCltrans-Cevimeline HCl
rac,trans-Cevimeline Hydrochloride
Cevimeline Impurity 7(trans-Cevimeline HCl)
(2S)-2-methylspiro[1,3-oxathiolane-5,3'-1-azabicyclo[2.2.2]octane]:hydrochloride
應(yīng)用領(lǐng)域
用途一
trans-Cevimeline HCl, also known as AF 102A, is the trans-isomer of AF102B (Cevimeline). Cevimeline is a cholinergic analogue with glandular secretion stimulatory activity. Cevimeline binds to and activates muscarinic receptors, thereby increasing the secretions in exocrine salivary and sweat glands. This cholinergic agonist also increases the tone of smooth muscle in the gastrointestinal and urinary tracts. Cevimeline is being studied as a treatment for dry mouth caused by radiation therapy to the head and neck.