109683-61-6
中文名稱(chēng)
烏替普利
英文名稱(chēng)
Utibapril
CAS
109683-61-6
分子式
C22H31N3O5S
分子量
449.569
MOL 文件
109683-61-6.mol
109683-61-6 結(jié)構(gòu)式
基本信息
中文別名
烏替普利 英文別名
UtibaprilFPL-63547
(2S)-5-tert-Butyl-3-[(2S)-2-[[(1S)-1-ethoxycarbonyl-3-phenylpropyl]amino]propanoyl]-2,3-dihydro-1,3,4-thiadiazole-2β-carboxylic acid
1,3,4-Thiadiazole-2-carboxylic acid, 5-(1,1-dimethylethyl)-3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-2,3-dihydro-, (2S)-
常見(jiàn)問(wèn)題列表
生物活性
Utibapril 是一種 angiotensin-converting enzyme (ACE) 抑制劑，具有抗高血壓的功效。體內(nèi)研究
Utibapril significantly inhibits plasma, renal, and vascular ACE but not ventricular ACE activity. Utibapril (2 μg/kg/day) significantly inhibits vascular ACE activity, and Utibapril (250 μg/kg/day) results in a significant inhibition of plasma ACE. Furthermore, angiotensin I-induced decreases in coronary flow in the isolated heart are significantly inhibited after treatment with the higher doses of utibapril. FPL 63547 is rapidly and extensively excreted as the diacid in the bile but appeared in the urine in negligible amounts.