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109770-29-8

中文名稱 BETA-AMYLOID (1-28)
英文名稱 H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH
CAS 109770-29-8
分子式 C145H209N41O46
分子量 3262.46
MOL 文件 109770-29-8.mol
更新日期 2026/05/28 07:46:34
109770-29-8 結(jié)構(gòu)式 109770-29-8 結(jié)構(gòu)式

基本信息

中文別名
Β淀粉樣蛋白(1-28)
AMYLOID Β肽(1-28)
Β淀粉樣肽(1-28)單克隆抗體
Β淀粉樣肽1-28/Β-AMYLOID 1-28抗體
英文別名
SP28
Fam-β-Amyloid
β-Amyloid (1-28)
BETA-AMYLOID (1-28)
AMyloid b-Protein (1-28)
AMYLOID BETA-PROTEIN (1-28)
DAEFRHDSGYEVHHQKLVFFAEDVGSNK
AMYLOID, BETA- (1-28), HUMAN
[Gln11] -β- Amyloid (1 - 28)
Human β-amyloid peptide(1-28)
所屬類別
生物化工:多肽

物理化學性質(zhì)

密度1.52±0.1 g/cm3(Predicted)
儲存條件−20°C
溶解度Soluble in DMSO
形態(tài)白色凍干粉末。
序列H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-OH

應(yīng)用領(lǐng)域

參考質(zhì)量標準
外觀:白色粉末
純度(HPLC) ≥98.0%
醋酸根含量5.0%~12.0%
水分含量≤8.0%
肽含量≥80.0%

安全數(shù)據(jù)

WGK Germany3
BETA-AMYLOID (1-28)價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2023/03/20HY-P1468BETA-AMYLOID (1-28)
β-Amyloid (1-28)
109770-29-81mg1600元
2023/03/20HY-P1468BETA-AMYLOID (1-28)
β-Amyloid (1-28)
109770-29-85mg6400元

常見問題列表

生物活性
β-Amyloid (1-28) 是可參與金屬結(jié)合的β-淀粉樣蛋白片段。β-淀粉樣蛋白是在阿爾茨海默病患者的腦中形成淀粉樣斑塊的肽。
靶點

Amyloid-β

體外研究

β-Amyloid Aggregation Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Solid Aβ peptide was dissolved in cold hexafluoro-2-propanol (HFIP). The peptide was incubated at room temperature for at least 1h to establish monomerization and randomization of structure.
2. The HFIP was removed by evaporation, and the resulting peptide was stored as a film at -20 or -80 ℃.
3. The resulting film was dissolved in anhydrous DMSO at 5 mM and then diluted into the appropriate concentration and buffer (serum- and phenol red-free culture medium) with vortexing.
4. Next, the solution was age 48h at 4-8 ℃. The sample was then centrifuged at 14000g for 10 min at 4-8 ℃; the soluble oligomers were in the supernatant. The supernatant was diluted 10-200-fold for experiments.

體內(nèi)研究

β-Amyloid (1-28) fragment is considered as valid models to examine the contribution of the key histidine residues (His , His in mouse and His , His , His in human fragments) to the Ab–Cu 2+ interaction. Copper binds to β-Amyloid (1-28) at pH 7.4 with an affinity of K a 10 7 M -1 .

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