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184865-04-1

中文名稱(chēng) 淀粉Β-蛋白
英文名稱(chēng) AMYLOID BETA-PROTEIN (29-40)
CAS 184865-04-1
分子式 C49H88N12O13S
分子量 1085.36
MOL 文件 184865-04-1.mol
184865-04-1 結(jié)構(gòu)式 184865-04-1 結(jié)構(gòu)式

基本信息

中文別名
淀粉Β-蛋白
AMYLOID Β-PROTEIN(30-40)
英文別名
Aβ29-40 peptide
β-Amyloid 29-40
β-Amyloid (29-40)
Amyloid β-Protein
amyloidβ-protein(30-40)
Amyloid β-Protein (29-40)
AMyloid b-Protein (29-40)
所屬類(lèi)別
生物化工:多肽

物理化學(xué)性質(zhì)

沸點(diǎn)1431.7±65.0 °C(Predicted)
密度1.179±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)3.35±0.10(Predicted)
序列Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val
淀粉Β-蛋白價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2023/03/20HY-P1522淀粉Β-蛋白
β-Amyloid (29-40)
184865-04-11mg800元
2023/03/20HY-P1522淀粉Β-蛋白
β-Amyloid (29-40)
184865-04-15mg2400元
2023/03/20HY-P1522淀粉Β-蛋白
β-Amyloid (29-40)
184865-04-110mg3900元

常見(jiàn)問(wèn)題列表

生物活性
β-Amyloid (29-40) 是 β 淀粉樣肽的一個(gè)片段。
靶點(diǎn)

Amyloid-β

體外研究

β-Amyloid (29-40) is a fragment of Amyloid-β peptide, unsoluble in water, acetonitrile or in a mixture of both in different ratios. Cationic arginine residues is introduced at β-Amyloid (29-40) C-terminus to solubilize β-Amyloid (29-40) and introduce cationicity in this Aβ stretch to enable it to interact with the negatively charged membrane of bacteria. β-Amyloid (29-40) variants shows antimicrobial effect. Single chain variable fragments (scFv's) binds the 17-28 region of Abeta and effectively inhibits in vitro aggregation of Abeta, but binding the carboxyl-terminal region of β-Amyloid (29-40) does not inhibit aggregation.
β-Amyloid Aggregation Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Solid Aβ peptide was dissolved in cold hexafluoro-2-propanol (HFIP). The peptide was incubated at room temperature for at least 1h to establish monomerization and randomization of structure.
2. The HFIP was removed by evaporation, and the resulting peptide was stored as a film at -20 or -80 ℃.
3. The resulting film was dissolved in anhydrous DMSO at 5 mM and then diluted into the appropriate concentration and buffer (serum- and phenol red-free culture medium) with vortexing.
4. Next, the solution was age 48h at 4-8 ℃. The sample was then centrifuged at 14000g for 10 min at 4-8 ℃; the soluble oligomers were in the supernatant. The supernatant was diluted 10-200-fold for experiments.
Methods vary depends on the downstream applications.

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