109944-15-2

中文名稱幾夫堿

英文名稱 KIFUNENSINE

CAS 109944-15-2

分子式 C8H12N2O6

分子量 232.19

MOL 文件 109944-15-2.mol

更新日期 2026/03/24 13:52:10

109944-15-2 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 幾夫堿價(jià)格(試劑級(jí)) 常見(jiàn)問(wèn)題列表

基本信息

中文別名

幾夫堿

英文別名

FR 900494
KIFUNENSINE
Kifunensine min. 99%
[5R-(5α,6β,7α,8α,8aα)]-
KIFUNENSINE, KITASATOSPORIA KIFUNENSE
Hexahydro-6R,7S,8aS-trihydroxy-5R-(hydroxymethyl)-imidazo[1,2-a] pyridine-2,3-dione
(5R,6R,7S,8R,8AS)-6,7,8-trihydroxy-5-(hydroxymethyl)hexahydroimidazo[1,2-a]pyridine-2,3-dione
(5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione
FR 900494, Hexahydro-6R,7S,8aS-trihydroxy-5R-(hydroxymethyl)-imidazo[1,2-a] pyridine-2,3-dione
Imidazo1,2-apyridine-2,3-dione, hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-, (5R,6R,7S,8R,8aS)-

物理化學(xué)性質(zhì)

熔點(diǎn)>280°C

密度1.85±0.1 g/cm3(Predicted)

儲(chǔ)存條件−20°C

溶解度二次蒸餾水中的溶解度：50MM

酸度系數(shù)(pKa)9.61±0.70(Predicted)

形態(tài)白色固體

顏色白色

生物來(lái)源synthetic (organic)

水溶解性Soluble to 5 mM in water with sonication

穩(wěn)定性干燥并儲(chǔ)存在-20°C

InChI1S/C8H12N2O6/c11-1-2-3(12)4(13)5(14)6-9-7(15)8(16)10(2)6/h2-6,11-14H,1H2,(H,9,15)/t2-,3-,4+,5+,6+/m1/s1

InChIKeyOIURYJWYVIAOCW-PQMKYFCFSA-N

SMILESN21[C@H](NC(=O)C2=O)[C@H]([C@H]([C@@H]([C@H]1CO)O)O)O

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險(xiǎn)性描述H319

防范說(shuō)明P264-P280-P305+P351+P338-P337+P313

WGK Germany3

海關(guān)編碼2939800000

存儲(chǔ)類別11 - Combustible Solids

危險(xiǎn)性類別Eye Irrit. 2

幾夫堿價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-19332R	幾夫堿 Kifunensine (Standard)	109944-15-2	1 mg	2500元
2026/06/05	HY-19332R	幾夫堿 Kifunensine (Standard)	109944-15-2	5 mg	6000元
2026/06/05	HY-19332	幾夫堿 Kifunensine	109944-15-2	1 mg	1364元

常見(jiàn)問(wèn)題列表

生物活性

Kifunensine 是可從放線菌中分離得到的 I 類 α-mannosidases 有效選擇性抑制劑，可阻斷 α-mannosidases I 修剪糖蛋白上的甘露糖殘基。Kifunensine 可抑制內(nèi)質(zhì)網(wǎng)相關(guān)蛋白降解途徑。

體外研究

Kifunensine, an alkaloid from actinomycete Kitasatosporia kifunense 9482, is the most efficient nhibitor of a-mannosidase I, blocking N-glycan synthesis at an8GlcNAc ₂ (Man8) or Man9GlcNAc ₂ (Man9) stage.

RT-PCR.

Cell Line:	Hybridoma cells expressing a human IgG1 monoclonal Antibody ^[3] .
Concentration:	2 μg/mL.
Incubation Time:	4 days.
Result:	Significantly reduced the lentil lectin binding. Kifunensine is the most effective among the inhibitors tested in producing antibodies containing oligomannose residues without fucose.

體內(nèi)研究