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111149-90-7

中文名稱 氯德拉苯
英文名稱 Declaben
CAS 111149-90-7
分子式 C25H41ClO3
分子量 425.04
MOL 文件 111149-90-7.mol
更新日期 2023/03/20 15:41:17
111149-90-7 結(jié)構(gòu)式 111149-90-7 結(jié)構(gòu)式

基本信息

中文別名
氯德拉苯
英文別名
SC-39026
Declaben
Lodelaben
Lodelabenum
Lodelabenum [inn-latin]
Benzoic acid, 2-chloro-4-(1-hydroxyoctadecyl)-

物理化學(xué)性質(zhì)

沸點(diǎn)539.8±40.0 °C(Predicted)
密度1.038±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)3.09±0.25(Predicted)
形態(tài)Solid
顏色White to off-white

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)有害 (GHS07)
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
防范說(shuō)明P261-P305+P351+P338
氯德拉苯價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2025/12/22HY-100240氯德拉苯
Lodelaben
111149-90-71 mg2380元
2025/12/22HY-100240氯德拉苯
Lodelaben
111149-90-75mg5910元

常見問(wèn)題列表

生物活性
Lodelaben 是一種人類嗜中性粒細(xì)胞彈性蛋白酶抑制劑,其 IC50 和 Ki 值分別 0.5 和 1.5 μM。
靶點(diǎn)

IC50: 0.5 μM (elastase) Ki: 1.5 μM (elastase)

體外研究

Lodelaben is a human neutrophil elastase inhibitor with an IC 50 and K i of 0.5 and 1.5 μM, respectively. Results indicate that the inhibition of human neutrophil elastase (HNE) by Lodelaben is non-competetive. Lodelaben is not inhibitory at 10 μM with the synthetic substrates or at 5 μM vith Azocoll. Pseudomonas aeruginosa elastase, a metallo-protease is not inhibited by Lodelaben. Cathepsin G activity, however, is inhibited by Lodelaben, with an IC 50 of approximately 2.5 μM, with Azocoll as substrate.

體內(nèi)研究

The mean pulmonary artery pressures of the saline/vehicle and saline/Lodelaben groups are similar, 16.4±1.1 and 17.4±0.9 mm Hg, respectively. Although, mean pulmonary artery pressure in the monocrotaline/vehicle group is 27.5±0.8 mm Hg, treatment of monocrotaline rats with Lodelaben results in significantly lower values (21.00±1.6 mm Hg, p<0.05). Saline/vehicle and saline/Lodelaben rats have only a small percentage of arteries muscularized at the alveolar wall level (1.9±1.4 and 0.4±0.4%, respectively). Treatment of monocrotaline-injected rats with Lodelaben results in a decreased percentage of alveolar wall arteries muscularized (10.0±3.6%).

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