113237-20-0
113237-20-0 結(jié)構(gòu)式
基本信息
2,6-二氯-5-氟煙酰胺
2,6-二氯-3-甲酰胺-5-氟吡啶
3,6-二氯-3-甲酰胺-5-氟吡啶
氟氯煙酰胺:2,6-二氯-3-甲酰胺-5-氟吡啶
2,6-DICHLORO-5-FLUORONICOTIMIDE
2,6-DICHLORO-5-FLUORONICOTINAMIDE
2,6-Dichloro-5-fluoronicotinamide97%
2,6-Dichloro-5-fluoronicotinamide 97%
2,6-DICHLORO-5-FLUOROPYRIDINE-3-CARBOXAMIDE
2,6-dichloro-3-carboxamide-5-fluoropyridine
3-PyridinecarboxaMide, 2,6-dichloro-5-fluoro-
2,6-DICHLORO-5-FLUORONICOTINAMIDE ISO 9001：2015 REACH
2,6-Dichloro-5-fluoropyridine-3-carboxamide, 3-Carbamoyl-2,6-dichloro-5-fluoropyridine
物理化學(xué)性質(zhì)
制備方法
82671-02-1
113237-20-0
實施例1A 2,6-二氯-5-氟煙酰胺的合成：將25g（130.90mmol）的3-氰基-2,6-二氯-5-氟吡啶懸浮于125ml濃硫酸中，于60-65℃下攪拌反應(yīng)1小時。反應(yīng)完成后，將混合物冷卻至室溫，隨后緩慢倒入冰水中。用乙酸乙酯（每次100ml）對水相進(jìn)行三次萃取。合并所有有機(jī)相，依次用100ml水和100ml飽和碳酸氫鈉水溶液洗滌。有機(jī)層經(jīng)無水硫酸鈉干燥后，在旋轉(zhuǎn)蒸發(fā)儀上濃縮。所得產(chǎn)物在高真空下進(jìn)一步干燥，最終得到24.5g白色固體，收率為90%。產(chǎn)物經(jīng)1H NMR（400MHz，DMSO-d6）表征：δ= 7.95（br s，1H），8.11（br s，1H），8.24（d，1H）。
參考文獻(xiàn)：
[1] Patent: CN108690016, 2018, A. Location in patent: Paragraph 0366; 0368; 0369
[2] Patent: WO2017/50807, 2017, A1. Location in patent: Page/Page column 132
[3] Patent: WO2011/147810, 2011, A1. Location in patent: Page/Page column 24
[4] Patent: US2012/22084, 2012, A1. Location in patent: Page/Page column 14
[5] Patent: US2013/172372, 2013, A1. Location in patent: Paragraph 0238; 0239; 0240; 0241