1139453-98-7
1139453-98-7 結(jié)構(gòu)式
基本信息
英丹尼布雜質(zhì)12
尼達(dá)尼布標(biāo)準(zhǔn)品003
N-(4-硝基苯基)-N,4-二甲基-1-哌嗪乙酰胺
N,4-二甲基-N-(4-硝基苯基)-1-哌嗪乙酰胺
N,4-二甲基-N-(4-硝基苯基)-1-哌嗪乙酰胺 10G
N-甲基-2-(4-甲基哌嗪-1-基)-N-(4-硝基苯基)乙酰胺
N-甲基-2-(4-甲基-1-哌嗪基)-N-(4-硝基苯基)乙酰胺
尼達(dá)尼布雜質(zhì)12:N-甲基-2-(4-甲基哌嗪-1-基)-N-(4-硝基苯基)-乙酰胺
N-METHYL-2-(4-METHYLPIPERAZIN-1-YL)-N-(4-NITROPHENYL)ACET...
Intedanib Impurity 12
Nintedanib Intermediate 1
N,4-Dimethyl-N-(4-nitrophenyl)-1-piperazineacetamide
1-Piperazineacetamide, N,4-dimethyl-N-(4-nitrophenyl)-
N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acet...
N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
N-Methyl-2-(4-methyl-1-piperazinyl)-N-(4-nitrophenyl)acetamide
N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetami...
N,4-Dimethyl-N-(4-Nitrophenyl)-1-Piperazineacetamide(Under Development)
物理化學(xué)性質(zhì)
制備方法
109-01-3
2653-16-9
1139453-98-7
以N-甲基哌嗪和2-氯-N-甲基-N-(4-硝基苯基)乙酰胺為原料合成N-甲基-2-(4-甲基哌嗪-1-基)-N-(4-硝基苯基)乙酰胺的一般步驟：將1-甲基哌嗪（7.2 mL，65 mmol）和碳酸鉀（13.8 g，100 mmol）溶于丙酮（200 mL）中，隨后緩慢加入2-氯-N-甲基-N-(4-硝基苯基)乙酰胺（11.4 g，50 mmol）。將反應(yīng)混合物在室溫下攪拌12小時(shí)。反應(yīng)完成后，過濾除去沉淀，濾液經(jīng)旋轉(zhuǎn)蒸發(fā)去除溶劑。將殘余物溶解于乙酸乙酯（50 mL × 3）中，并用20 mL水進(jìn)行萃取。有機(jī)相用無水硫酸鈉干燥后，減壓濃縮除去溶劑，得到15 g目標(biāo)化合物。LC-MS分析顯示：m/z = 293（[M+H]+）。
參考文獻(xiàn)：
[1] Patent: WO2009/71524, 2009, A2. Location in patent: Page/Page column 21-22; 13
[2] Patent: WO2009/71524, 2009, A2. Location in patent: Page/Page column 21-22; 13
[3] Patent: WO2009/71523, 2009, A1. Location in patent: Page/Page column 4; 23-24
[4] Patent: WO2009/71523, 2009, A1. Location in patent: Page/Page column 4; 24
[5] Journal of Labelled Compounds and Radiopharmaceuticals, 2015, vol. 58, # 7, p. 308 - 312