116289-53-3
116289-53-3 結構式
基本信息
中文別名
妥洛帕泛 英文別名
Tulopafant1H,3H-Pyrrolo[1,2-c]thiazole-7-carboxamide, N-(3-benzoylphenyl)-3-(3-pyridinyl)-, (+)-
物理化學性質
沸點613.3±55.0 °C(Predicted)
密度1.32±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(pKa)13.51±0.70(Predicted)
常見問題列表
生物活性
Tulopafant 是血小板激活因子 (PAF) 拮抗劑。體外研究
Preincubation of neutrophils with Tulopafant (RP 59227) results in a concentration-dependent decrease in chemiluminescence produced by PAF primed cells.
體內研究
Tulopafant (RP 59227) effectively reduces myocardial infarct size and reduces the incidence of ischemia and reperfusion-induced arrhythmias in barbital-anesthetized dogs.Histological examination reveals marked diminution of both interstitial hemorrhage and deposition of platelet and granulocytes in capillaries of cardiac xenografts when recipient animals are pretreated with Tulopafant.