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1163-36-6

中文名稱 1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑鹽酸鹽
英文名稱 Clemizole hydrochloride
CAS 1163-36-6
EINECS 編號 214-605-4
分子式 C19H21Cl2N3
MDL 編號 MFCD00051435
分子量 362.3
MOL 文件 1163-36-6.mol
更新日期 2026/07/13 11:29:07
1163-36-6 結(jié)構(gòu)式 1163-36-6 結(jié)構(gòu)式

基本信息

中文別名
1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑鹽酸鹽
鹽酸氯咪唑
英文別名
1-[(4-Chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzoimidazole hydrochloride
1-P-CHLOROBENZYL-2-[1-PYRROLIDINYL]-METHYLBENZIMIDAZOLE HYDROCHLORIDE
CLEMIZOLE HCL
CLEMIZOLE HYDROCHLORIDE
LABOTEST-BB LT00453174
1-(p-chlorobenzil)-2-pirrolidil-metil-benzimidazolocloridato
1-(p-chlorobenzyl)-2-(1-pyrrolidinylmethyl)-benzimidazolmonohydrochloride
1-p-chlorobenzyl-pyrrolidyl-methylene-benzimidazolehydrochloride
allercur
allercurehydrochloride
p48
1-(4-Chlorophenyl)methyl)-2-(1-pyrrolidinylmethyl)-(1H)-benzimidazoleHCl
1-(P-CHLOROBENZYL)-2-(1-PYRROLIDINYLMETHYL)-BENZIMIDAZOL
所屬類別
生物化工:激動劑抑制劑

物理化學(xué)性質(zhì)

熔點(diǎn)239-241°
儲存條件Inert atmosphere,2-8°C
溶解度在水中的溶解度為性2mg/mL,澄清(加熱)
形態(tài)粉末
顏色白色至米色
水溶解性16.84mg/L at 25℃
Merck13,2368
InChIInChI=1S/C19H20ClN3.ClH/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22;/h1-2,5-10H,3-4,11-14H2;1H
InChIKeyDNFMJYXRIMLMBZ-UHFFFAOYSA-N
SMILESN1(CC2C=CC(Cl)=CC=2)C(CN2CCCC2)=NC2C=CC=CC1=2.Cl
LogP1.99
CAS 數(shù)據(jù)庫1163-36-6(CAS DataBase Reference)

安全數(shù)據(jù)

危險(xiǎn)性符號(GHS)有害 (GHS07)
GHS07
警示詞警告
危險(xiǎn)性描述H302
防范說明P301+P312+P330
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼R22
安全說明S36
WGK Germany3
RTECS號DD6730000
REACH 注冊登記Active
海關(guān)編碼2933.99.8290
存儲類別11 - Combustible Solids
危險(xiǎn)性類別Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1

應(yīng)用領(lǐng)域

用途一
用作氯咪唑青霉素等藥物的中間體
1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑鹽酸鹽價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2026/06/06C3468鹽酸克立咪唑
Clemizole Hydrochloride
1163-36-625mg1120元
2026/06/06C3468鹽酸克立咪唑
Clemizole Hydrochloride
1163-36-6100mg4450元
2026/06/05HY-30234A1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑鹽酸鹽
Clemizole hydrochloride
1163-36-65mg500元

常見問題列表

生物活性
Clemizole hydrochloride 是一種 H1 組胺受體 (H1 histamine receptor) 拮抗劑,抑制 HCV 復(fù)制。
靶點(diǎn)

IC50: 24 nM (NS4B)
H1 histamine receptor

體外研究

Clemizole hydrochloride is found to inhibit HCV RNA replication in cell culture that is mediated by its suppression of NS4B’s RNA binding, with little toxicity for the host cell. The EC 50 of Clemizole on the W55R mutant J6/JFH RNA is ~18 μM (2.25 times the EC 50 of the wild-type RNA). Clemizole is a novel inhibitor of TRPC5 channels. Clemizole efficiently blocks TRPC5 currents and Ca 2+ entry in the low micromolar range (IC 50 =1.0-1.3 μM). Clemizole exhibits a six-fold selectivity for TRPC5 over TRPC4β (IC 50 =6.4 μM), the closest structural relative of TRPC5, and an almost 10-fold selectivity over TRPC3 (IC 50 =9.1 μM) and TRPC6 (IC 50 =11.3 μM). Clemizole hydrochloride as a novel blocker of TRPC5 with a half-maximal inhibitory concentration of 1.1 μM. The concentration-response curves confirmed a concentration-dependent block of TRPC5 by Clemizole and revealed an apparent IC 50 of 1.1±0.04 μM.

體內(nèi)研究

Clemizole hydrochloride has an unexpectedly short plasma half-life (measured at 0.15 hours); it is very rapidly biotransformed into a glucuronide (M14) and a dealkylated metabolite (M12) and into a variety of lesser metabolites in C57BL/6J mice.

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