117857-45-1

中文名稱氯瑞唑

英文名稱 (Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)ethenyl)-(1H)-1,2,4-triazolehydrochloride

CAS 117857-45-1

分子式 C10H6Cl3N3

分子量 274.53

MOL 文件 117857-45-1.mol

更新日期 2023/03/20 15:41:25

117857-45-1 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息氯瑞唑價(jià)格(試劑級(jí)) 常見(jiàn)問(wèn)題列表

基本信息

中文別名

氯瑞唑

英文別名

R-72063
Loreclezole
LoreclezoleHCl
1-[(Z)-2-chloro-2-(2,4-dichlorophenyl)ethenyl]-1,2,4-triazole
1-[(Z)-2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole
1H-1,2,4-Triazole, 1-[(1Z)-2-chloro-2-(2,4-dichlorophenyl)ethenyl]-
(Z)-1-(2-Chloro-2-(2,4-dichlorophenyl)vinyl)-1H-1,2,4-triazole hydrochloride

物理化學(xué)性質(zhì)

儲(chǔ)存條件Inert atmosphere,2-8°C

溶解度<1.37mg/ml in DMSO; <1.37mg/ml in ethanol

形態(tài)Solid

顏色White to off-white

InChI1S/C10H6Cl3N3/c11-7-1-2-8(9(12)3-7)10(13)4-16-6-14-5-15-16/h1-6H/b10-4-

InChIKeyXGLHZTBDUXXHOM-WMZJFQQLSA-N

SMILESCl/C(C1=CC=C(Cl)C=C1Cl)=C\N2N=CN=C2

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險(xiǎn)性描述H302-H315-H319-H335

防范說(shuō)明P261-P305+P351+P338

WGK GermanyWGK 3

存儲(chǔ)類別11 - Combustible Solids

圖譜信息

氯瑞唑(117857-45-1)核磁圖(¹HNMR)

氯瑞唑價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-105272R	氯瑞唑 Loreclezole (Standard)	117857-45-1	5 mg	1500元
2026/06/05	HY-105272	氯瑞唑 Loreclezole	117857-45-1	1 mg	266元
2026/06/05	HY-105272R	氯瑞唑 Loreclezole (Standard)	117857-45-1	10 mg	2250元

常見(jiàn)問(wèn)題列表

生物活性

Loreclezole 是一種抗癲癇化合物，是選擇性的 GABAA 受體的調(diào)節(jié)劑，是 β2 或 β3 亞單位包含受體的正向變構(gòu)調(diào)節(jié)劑。

靶點(diǎn)

GABA _A receptor.

體內(nèi)研究

Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the “pull-up” test.

Animal Model:	Adult male Lister Hooded rats.
Dosage:	10, 25, 50 or 75 mg/kg.
Administration:	IP, 60 min before measurement of seizure threshold.
Result:	Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later.