119615-63-3
中文名稱
鹽酸奧普力農
英文名稱
OLPRINONE HYDROCHLORIDE
CAS
119615-63-3
分子式
C14H11ClN4O
分子量
286.72
MOL 文件
119615-63-3.mol
更新日期
2026/05/25 12:42:16
119615-63-3 結構式
基本信息
中文別名
鹽酸奧普力農化合物 T5033L
1,2-二氫-5-咪唑并[...
英文別名
e1020Coretec
OLPRINONE HCL
xo-,monohydrochloride,monohydrate
3-pyridinecarbonitrile,1,2-dihydro-5-(imidazo(1,2-a)pyridin-6-yl)-6-methyl-2-o
1,2-Dihydro-5-imidazo[1,2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile Hydrochloride
3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-,monohydrochloride
Loprinone hydrochloride, 1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride
所屬類別
有機原料：羧酸類化合物及衍生物物理化學性質
熔點>3000C
儲存條件2-8°C
溶解度DMSO: ≤4 mg/mL
形態(tài)solid
顏色beige
InChIInChI=1S/C14H10N4O.ClH/c1-9-12(6-11(7-15)14(19)17-9)10-2-3-13-16-4-5-18(13)8-10;/h2-6,8H,1H3,(H,17,19);1H
InChIKeyPWTBMBAQRAOAFF-UHFFFAOYSA-N
SMILESCC1NC(=O)C(C#N)=CC=1C1C=CC2=NC=CN2C=1.Cl
常見問題列表
生物活性
Olprinone (Loprinone) Hydrochloride 是一種有效的磷酸二酯酶 (PDE) 3 抑制劑，對 PDE1，PDE2，PDE3，PDE4 的 IC50 分別為 150、100、0.35 和 14 μM。Olprinone Hydrochloride 因其正性肌力和血管擴張作用而被用于心力衰竭的研究。Olprinone Hydrochloride 具有抗炎活性。體內研究
Olprinone (Loprinone) Hydrochloride (0.2 mg/kg; i.p.) modulates the inflammation associated with myocardial ischemia-reperfusion injury in rats.
| Animal Model: | Male adult Wistar rats (250-300 g) (ischemia–reperfusion rats) |
| Dosage: | 0.2 mg/kg |
| Administration: | I.p. (administered 15 min after ischemia) |
| Result: | Significantly reduced the: (1) histological evidence of myocardial injury, (2) pro-inflammatory cytokines: tumor necrosis factor-α (TNF-α) and Interleukin-1β (IL-1β), (3) adhesion molecules: Inter-Cellular Adhesion Molecule 1 (ICAM-1) and P-Selectin, (4) nitrotyrosine formation, (5) nuclear factor kappa-B (NF-κB) expression, (6) Poly (ADP-ribose) (PAR) formation, and (7) apoptosis (Bax, Bcl-2, Fas-L and terminal deoxynucleotidyl transferase-mediated UTP end labeling (TUNEL). |