1210419-26-3
1210419-26-3 結(jié)構(gòu)式
基本信息
6-溴-5-氟吡啶-2-羧酸甲酯
2-溴-3-氟-6-甲酸甲酯吡啶
6-溴-5-氟-2-吡啶甲酸甲酯
6-bromo-5-fL
methyl 6-bromo-5-fluoropicolinat
Methyl 6-bromo-5-fluoropicolinate
N'-(3,4-dichlorophenyl)ethane-1,6-diamine
Methyl 6-bromo-5-fluoropyridine-2-carboxylate
6-Bromo-5-fluoro-pyridine-2-carboxylic acid methyl ester
2-Pyridinecarboxylic acid, 6-bromo-5-fluoro-, methyl ester
Methyl 6-bromo-5-fluoropicolinate, 2-Bromo-3-fluoro-6-(methoxycarbonyl)pyridine
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
67-56-1
1052714-46-1
1210419-26-3
6-溴-5-氟吡啶甲酸甲酯的合成：向6-溴-5-氟-2-吡啶甲酸（1.0當(dāng)量）的甲醇（0.2M）溶液中緩慢加入濃硫酸（4.2當(dāng)量），于室溫下攪拌反應(yīng)混合物。反應(yīng)進(jìn)程通過(guò)LC/MS監(jiān)測(cè)，約2小時(shí)后反應(yīng)完成。將反應(yīng)混合物用乙酸乙酯稀釋，并緩慢加入飽和碳酸氫鈉水溶液以淬滅反應(yīng)。將混合物轉(zhuǎn)移至分液漏斗中，用乙酸乙酯萃取。合并有機(jī)相，用無(wú)水硫酸鎂干燥，過(guò)濾后減壓濃縮，得到6-溴-5-氟吡啶甲酸甲酯，為白色固體（產(chǎn)率>99%）。產(chǎn)物經(jīng)LC/MS表征：m/z = 233.9/235.9（[M+H]+），保留時(shí)間Rt = 0.69 min。
參考文獻(xiàn)：
[1] Patent: US2010/56576, 2010, A1. Location in patent: Page/Page column 48
[2] Patent: WO2012/4217, 2012, A1. Location in patent: Page/Page column 65-66
[3] Patent: US2012/225062, 2012, A1. Location in patent: Page/Page column 26; 27
[4] Patent: US2012/225061, 2012, A1. Location in patent: Page/Page column 22
[5] Patent: WO2013/175388, 2013, A1. Location in patent: Page/Page column 44