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12279-41-3

中文名稱 絲拉克肽
英文名稱 Seractide
CAS 12279-41-3
分子式 C207H308N56O58S1
分子量 4541.07
MOL 文件 12279-41-3.mol
更新日期 2026/06/01 19:17:32
12279-41-3 結(jié)構(gòu)式 12279-41-3 結(jié)構(gòu)式

基本信息

中文別名
六氟硅酸
絲拉克肽
人ACTH (1-39)肽
促腎上腺皮質(zhì)激素(1-39)
絲拉克肽, ≥97% (HPLC)
英文別名
ACTH
ACTH 1-39
Seractide
CORTICOTROPHIN
Seractide ACTH
CORTICOTROPIN A
Seractide acetate
ACTH (1-39), HUMAN
Seractide USP/EP/BP
CORTICOTROPIN (HUMAN)
所屬類別
生物化工:多肽

物理化學(xué)性質(zhì)

儲(chǔ)存條件−20°C
儲(chǔ)存條件Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度H2O: 1 mg/mL, clear, colorless
溶解度H2O:1 mg/mL,澄清,無(wú)色
形態(tài)固體
顏色White to off-white
水溶解性Soluble to 1 mg/ml in water
序列H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH
InChIKeyIDLFZVILOHSSID-BUSJYVCNNA-N

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)有害 (GHS07)健康危害 (GHS08)
GHS07,GHS08
警示詞警告
危險(xiǎn)性描述H302+H312+H332-H351
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼20/21/22-40
安全說(shuō)明22-36
WGK Germany3
WGK Germany3
RTECS號(hào)GM7900000
存儲(chǔ)類別11 - Combustible Solids
危險(xiǎn)性類別Acute Tox. 4 Oral
Carc. 2

應(yīng)用領(lǐng)域

用途1
可用于生產(chǎn)促腎上腺皮質(zhì)激素(ACTH),助應(yīng)素。在獸藥生產(chǎn)上,可用于促黃體激素和促卵泡激素的生產(chǎn)。
參考質(zhì)量標(biāo)準(zhǔn)
外觀?白色粉末純度(HPLC) ≥95.0%
醋酸根含量5.0%~12.0%
水分含量≤8.0%
肽含量≥80.0%

常見問題列表

理化性質(zhì)
類白色粉末,有特臭。
貯存
儲(chǔ)存溫度:-20℃
生物活性
Adrenocorticotropic Hormone (ACTH) (1-39), human 是一種黑皮質(zhì)素受體 (melanocortin receptor) 激動(dòng)劑。
靶點(diǎn)

Melanocortin receptor

體外研究

Adrenocorticotropic Hormone (ACTH) (1-39), human (ACTH 1-39), a member of the melanocortin family, stimulates production of CS by the adrenals, but melanocortin receptors are also found in the central nervous system (CNS) and on immune cells. ACTH 1-39 protects neurons in vitro from several apoptotic, excitotoxic and inflammation-related insults. The conditioned medium (CM) is prepared from untreated astroglia (AS) cultures and from AS cultures treated with 200 nM ACTH 1-39 for 24 h, washed to remove ACTH 1-39, then incubated for another 24 h in DMEM. In initial experiments, no difference is found in oligodendroglia (OL) viability in the presence of OL definedmediumwith 2% newborn calf serum (NCS) or AS CM (prepared in DMEM with no serum). After 24 h, OL death under each condition varies between 1 and 4%. Similar results for OL viability are obtained with microglia (MG) CM. In subsequent experiments, controls in each experiment consist of OL in defined medium with 2% NCS.

絲拉克肽價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2026/06/05HY-P1211絲拉克肽
Adrenocorticotropic Hormone (ACTH) (1-39), human
12279-41-31mg680元
2026/06/05HY-P1211絲拉克肽
Adrenocorticotropic Hormone (ACTH) (1-39), human
12279-41-35mg1600元
2026/06/05HY-P1211絲拉克肽
Adrenocorticotropic Hormone (ACTH) (1-39), human
12279-41-310mg2600元
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