1231930-37-2
1231930-37-2 結構式
基本信息
LY2835219中間體4
LY2835219中間體三
ABEMACICLIB 雜質(zhì)2
1H-苯并咪唑-4-氟-2-甲基-1-異丙基-6-硼酸頻吶醇酯
4-氟-1-異丙基-2-甲基-6-硼酸頻哪醇酯基-1H-苯并[D]咪唑
4-氟-1-異丙基-2-甲基-6-(4,4,5,5-四甲基-1,3,2-二氧硼雜環(huán)戊烷-2-基)-1
4-氟-1-異丙基-2-甲基-6-(4,4,5,5-四甲基-[1,3,2]二氧硼戊環(huán)-2-基)-1H-苯并咪唑
4-氟-2-甲基-1-異丙基-6-(4,4,5,5-四甲基-1,3,2-二氧雜環(huán)戊硼烷-2-基)-1H-苯并咪唑
4-氟-1-異丙基-2-甲基-6-(4,4,5,5-四甲基-1,3,2-二氧硼戊烷-2-基)-1H-苯并[D]咪唑
intermediate-1(Abemaciclib)
(4-FLUORO-1-ISOPROPYL-2-METHYL-1H-BENZO[D]IMIDAZOL-6-YL)BORONIC ACID PINACOL ESTER
4-fluoro-2-methyl-1-propan-2-yl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzimidazole
4-fluoro-2-methyl-1-(propan-2-yl)-6-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-1,3-benzodiazole
4-FLUORO-1-ISOPROPYL-2-METHYL-6-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-1H-BENZOIMIDAZOLE
4-fluoro-1-isopropyl-2-Methyl-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]iMidazole
4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1H-benzo[d]imidazole
1H-BENZIMIDAZOLE, 4-FLUORO-2-METHYL-1-(1-METHYLETHYL)-6-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN- 2-Y
4-Fluoro-2-methyl-1-(1-methylethyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole
物理化學性質(zhì)
制備方法
![6-溴-4-氟-1-異丙基-2-甲基-1H-苯并[D]咪唑](/CAS/GIF/1231930-33-8.gif)
1231930-33-8
73183-34-3
1231930-37-2
以6-溴-4-氟-1-異丙基-2-甲基-1H-苯并[D]咪唑和聯(lián)硼酸頻那醇酯為原料，合成4-氟-1-異丙基-2-甲基-6-硼酸頻哪醇酯基-1H-苯并[d]咪唑的一般步驟如下：在500 mL單頸燒瓶中加入DMSO（100 mL），隨后依次加入6-溴-4-氟-1-異丙基-2-甲基-1H-苯并[D]咪唑（20.0 g，73.80 mmol）、雙（頻哪醇合）二硼（27.6 g，108.69 mmol）、三環(huán)己基膦（3.53 g，12.61 mmol）和乙酸鉀（21.3 g，217.38 mmol）。迅速加入乙酸鈀（1.5 g）后，向反應燒瓶中通入氮氣進行保護，隨后在氮氣氛圍下加熱至90℃。反應3小時后，將反應燒瓶冷卻至室溫，將反應混合物倒入700 mL水中，充分攪拌后進行減壓過濾。濾餅用100 mL水洗滌兩次，干燥后得到淺棕色固體。將粗產(chǎn)物用50 mL石油醚和10 mL乙酸乙酯打漿10分鐘，經(jīng)過真空過濾得到白色固體（18.8 g，收率80.3%）。
參考文獻：
[1] Patent: CN107266421, 2017, A. Location in patent: Paragraph 0042; 0043; 0050; 0051
[2] Patent: CN104910137, 2017, B. Location in patent: Paragraph 0213; 0220-0222
[3] Patent: EP3091008, 2016, A1. Location in patent: Paragraph 0177; 0178
[4] Patent: US2010/160340, 2010, A1. Location in patent: Page/Page column 10
[5] Patent: WO2015/130540, 2015, A1. Location in patent: Page/Page column 22