1261728-71-5
中文名稱
7-(二氟甲基)喹啉
英文名稱
7-(Difluoromethyl)Quinoline
CAS
1261728-71-5
分子式
C10H7F2N
分子量
179.17
MOL 文件
1261728-71-5.mol
更新日期
2026/07/31 15:09:38
1261728-71-5 結(jié)構(gòu)式
基本信息
中文別名
7-(二氟甲基)喹啉 英文別名
7-(Difluoromethyl)QuinolineQuinoline, 7-(difluoromethyl)-
7-(Difluoromethyl)Quinoline(WXC01613)
物理化學(xué)性質(zhì)
儲存條件Storage temp. 2-8°C
外觀Light yellow to yellow Oil
InChIInChI=1S/C10H7F2N/c11-10(12)8-4-3-7-2-1-5-13-9(7)6-8/h1-6,10H
InChIKeyCPYCSVBOWJMMBM-UHFFFAOYSA-N
SMILESN1C2C(=CC=C(C(F)F)C=2)C=CC=1
應(yīng)用領(lǐng)域
用途一
7-(Difluoromethyl)quinoline is an intermediate in the synthesis of GNE-781 (D447825), a derivative of a highly advanced, potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP). Inhibition of the bromodomain of the transcriptional regulator CBP/P300 is an especially interesting new therapeutic approach in oncology.