1263373-43-8

中文名稱化合物NVP-2

英文名稱 4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile

CAS 1263373-43-8

分子式 C27H37ClN6O2

分子量 513.07

MOL 文件 1263373-43-8.mol

更新日期 2026/06/05 17:25:46

1263373-43-8 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息化合物NVP-2價(jià)格(試劑級(jí)) 常見問題列表

基本信息

中文別名

化合物NVP-2

英文別名

NVP-2
4-((5'-chloro-2'-((1R,4r)-4-((R)-1-methoxypropan-2-ylamino)cyclohexylamino)-2,4'-bipyridin-6-ylamino)methyl)tetrahydro-2H-pyran-4-carbonitrile
4-[[[5'-Chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile
2H-Pyran-4-carbonitrile, 4-[[[5'-chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-

所屬類別

生物化工：CDK 抑制劑

物理化學(xué)性質(zhì)

沸點(diǎn)704.5±60.0 °C(Predicted)

密度1.23±0.1 g/cm3(Predicted)

儲(chǔ)存條件-20°C儲(chǔ)存

溶解度可溶于乙醇

酸度系數(shù)(pKa)9.14±0.40(Predicted)

形態(tài)固體

顏色White to yellow

InChIKeyXWQVQSXLXAXOPJ-NJDAHSKKSA-N

SMILESC1OCCC(CNC2N=C(C3C(Cl)=CN=C(N[C@@H]4CC[C@@H](N[C@H](C)COC)CC4)C=3)C=CC=2)(C#N)C1

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險(xiǎn)性描述H315-H319

防范說明P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

WGK GermanyWGK 3

存儲(chǔ)類別11 - Combustible Solids

圖譜信息

化合物NVP-2(1263373-43-8)核磁圖(¹HNMR)

化合物NVP-2價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-12214A	化合物NVP-2 NVP-2	1263373-43-8	1 mg	600元
2026/06/05	HY-12214A	化合物NVP-2 NVP-2	1263373-43-8	5mg	1500元
2026/06/05	HY-12214A	化合物NVP-2 NVP-2	1263373-43-8	10mM * 1mLin DMSO	1693元

常見問題列表

生物活性

NVP-2 是一種有效的、選擇性的、非神經(jīng)毒性和ATP競(jìng)爭(zhēng)性的 cyclin dependent kinase 9 (CDK9) 的抑制劑，對(duì)CDK9/CycT活性的IC50值為0.514 nM，并可誘導(dǎo)細(xì)胞凋亡。

靶點(diǎn)

Target	Value
CDK9/CycT (Cell-free assay)	0.514 nM

體外研究

NVP-2 has an anti-proliferation of leukemia cells, inhibits KOPT-K1, Jurkat, P12-ICHIKAWA, DU.528, MOLT 16, HSB-2, PF-382, SKW-3, SUP-T11, DND-41 and HPB-ALL cells with IC ₅₀ values of 0.1688 μM, 0.1233 μM,0.5736 μM,0.1575 μM, 0.1620 μM,0.1585 μM, 0.1808 μM, 0.2589 μM, 0.0918 μM and 0.3023 μM, respectively. NVP-2 (250 nM-1 μM; 6 hours) engages CDK9 in wildtype and?CRBN ^?/? MOLT4 cells at all concentrations, while CDK2 and CDK7 are unaffected. NVP-2 (0-10 nM; 72 hours) exhibits CRBN-dependent anti-proliferative and pro-apoptotic effects in MOLT4 cells, displays an IC ₅₀ value of 9 nM. NVP-2 (250 nM; 24 hours) induces cell apoptosis in MOLT4 cells, upregulates caspase-3 and γH2A.X expression. However, while the compound washout significantly reduces the degree of apoptosis induced by NVP-2.

Cell Viability Assay

Cell Line:	Leukemia cell lines
Concentration:	0.1233 μM-0.5736 μM
Incubation Time:	72 hours
Result:	Inhibited Leukemia cell lines viabity.

Western Blot Analysis

Cell Line:	Wildtype and?CRBN ^?/? MOLT4 cells
Concentration:	1 μM; 500 nM; 250 nM
Incubation Time:	6 hours
Result:	Degrade CDK9 ?sub-stoichiometrically at all concentrations.

Apoptosis Analysis

Cell Line:	Wildtype and?CRBN ^?/? MOLT4 cells
Concentration:	250 nM
Incubation Time:	24 hours
Result:	Induced cell apoptosis in cells and wash outed the compound relieved NVP-2-induced cell apoptosis.

Cell Proliferation Assay

Cell Line:	MOLT4 cells
Concentration:	0-10 nM
Incubation Time:	72 hours
Result:	Exhibited anti-proliferative effects in MOLT4 cells.