1290541-46-6
1290541-46-6 結(jié)構(gòu)式
基本信息
RAD51抑制劑(RAD51 INHIBITOR B02)
B02
CS-2461
RAD51 Inhibitor B02
RAD51 Inhibitor B02 >=98% (HPLC)
RAD51 Inhibitor, B02 - CAS 1290541-46-6 - Calbiochem
(E)-3-benzyl-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one
3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone
4(3H)-Quinazolinone, 3-(phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-101462 | RAD51 Inhibitor B02 | 1290541-46-6 | 1 mg | 308元 |
| 2026/06/05 | HY-101462 | RAD51 INHIBITOR B02 RAD51 Inhibitor B02 | 1290541-46-6 | 5mg | 770元 |
| 2026/06/05 | HY-101462 | RAD51 INHIBITOR B02 RAD51 Inhibitor B02 | 1290541-46-6 | 10mM * 1mLin DMSO | 847元 |
常見問題列表
IC50: 27.4 μM (hRAD51)
RAD51 Inhibitor B02 specifically inhibits human RAD51 (IC 50 =27.4 μM), but not its E. coli homologue RecA (IC 50 >250 μM). The combination of B02 with cisplatin has the strongest killing effect on the human breast cancer cells MDA-MB-231.
B02 significantly enhances the therapeutic effect of cisplatin on tumor cells in vivo . B02 is tolerated by mice at doses up to 50 mg/kg without obvious body weight loss. No inhibition of tumor growth is observed on mice solely treated by B02. Mice treated with 4 mg/kg cisplatin, however, shows a 33% inhibition of tumor growth. Finally, mice treated with 50 mg/kg B02 and 4 mg/kg cisplatin shows a 66% inhibition of tumor growth.