129203-60-7
129203-60-7 結(jié)構(gòu)式
基本信息
毒素多肽IBERIOTOXIN
RLBTX
IBERIOTOXIN
IBERIOTOXIN 98%
IBERIOTOXIN USP/EP/BP
IBERIOTOXIN, RECOMBINANT
IBERIOTOXIN, BUTHUS TAMULUS
IBTX (SCORPION, BUTHUS TAMULUS)
iberiotoxin from buthus tamulus
M.W. 4230.91 C179H274N50O55S7
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
very toxic hazardous materials
Acute Tox. 2 Dermal
Acute Tox. 2 Oral
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/12/22 | HY-P0190 | IBERIOTOXIN毒素肽 Iberiotoxin | 129203-60-7 | 100μg | 1125元 |
| 2025/12/22 | HY-P0190 | IBERIOTOXIN毒素肽 Iberiotoxin | 129203-60-7 | 500 μg | 2790元 |
| 2025/12/22 | HY-P0190 | IBERIOTOXIN毒素肽 Iberiotoxin | 129203-60-7 | 1 mg | 4500元 |
常見問題列表
Kd: 1 nM (Ca 2+ -activated K + channel)
Iberiotoxin reversibly blocks Ca2+-activated K+ channel in excised membrane patches from bovine aortic smooth muscle. Iberiotoxin acts exclusively at the outer face of the channel and functions with IC
50
values of about 250 pM. Iberiotoxin is a partial inhibitor of
125
I-charybdotoxin binding in bovine aortic sarcolemmal membrane vesicles (Ki of 2
50
pM). Iberiotoxin functions as a noncompetitive inhibitor of charybdotoxin binding.
Iberiotoxin treatment affects rat mesenchymal stem cells (rMSCs) migration in the absence of platelet lysate (PL) by inducing a decrease in cell migration suggesting that BK channels regulate rMSCs migration in basal conditions. 10 nM of Iberiotoxin abolishes the PL-induced migration effect on MSCs.
Male Wistar rats (6-7 weeks old) with chronic heart failure (CHF), Iberiotoxin (0.125 nmol/nl, 1.25 nmol/nl and 12.5 nmol/nl) is infused into paraventricular hypothalamic nucleus (PVN) by osmotic minipumps. After perfusion of Iberiotoxin by microinjection of rAAV2-KCNMB4 shRNA virus, right ventricular weight/body weight and lung weight/body weight ratio as well as left ventricular end-diastolic diameter are increased and left ventricular ejection fraction is decreased.