1293281-49-8
中文名稱
[2-(4,6-DIMETHYLPYRIMIDIN-2-YL)-1,3,3A,4,6,6A-HEXAHYDROPYRROLO[3,4-C]PYRROL-5-YL]-[2-FLUORO-6-(TRIAZOL-2-YL)PHENYL]METHANONE
英文名稱
JNJ-42847922
CAS
1293281-49-8
分子式
C21H22FN7O
分子量
407.44
MOL 文件
1293281-49-8.mol
更新日期
2026/05/25 08:48:03
1293281-49-8 結(jié)構(gòu)式
基本信息
中文別名
(5-(4,6-二甲基嘧啶-2-基)六氫吡咯并[3,4-C]吡咯-2(1H)-基)(2-氟-6-(2H-1,2,3-三唑-2-基)苯基)甲酮 英文別名
JNJ-42847922JNJ-42847922,Cid 67116280
[5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone
Methanone, [5-(4,6-dimethyl-2-pyrimidinyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl][2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl]-
[2-(4,6-DIMETHYLPYRIMIDIN-2-YL)-1,3,3A,4,6,6A-HEXAHYDROPYRROLO[3,4-C]PYRROL-5-YL]-[2-FLUORO-6-(TRIAZOL-2-YL)PHENYL]METHANONE
所屬類別
有機(jī)原料：雜環(huán)化合物物理化學(xué)性質(zhì)
沸點(diǎn)667.7±65.0 °C(Predicted)
密度1.46±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 250 mg/mL (613.59 mM)
酸度系數(shù)(pKa)6.50±0.50(Predicted)
形態(tài)Solid
顏色White to yellow
應(yīng)用領(lǐng)域
用途一
Seltorexant, also known as JNJ-42847922 and MIN-202, is a potent OX2R antagonist that has been shown to promote sleep in various species. JNJ-42847922 had an approximate 2-log selectivity ratio versus the human orexin-1 receptor. Ex vivo receptor binding studies demonstrated that JNJ-42847922 quickly occupied OX2R binding sites in the rat brain after oral administration and rapidly cleared from the brain. Seltorexant shows antidepressant and sleep-promoting effects in patients with major depressive disorder. JNJ-42847922 induces somnolence in healthy subjects without residual central effects.常見問題列表
概述
Seltorexant (JNJ-42847922) 是一種具有口服活性的，高親和性以及選擇性的 orexin-2 受體 (OX2R) 拮抗劑 (人和大鼠中的 OX2R 的pKi 值分別為 8.0 和 8.1)。Seltorexant (JNJ-42847922) 穿過血腦屏障，迅速占據(jù)大鼠大腦中的 OX2R 結(jié)合位點(diǎn)。JNJ-42847922價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/03/03 | S3503 | [2-(4,6-DIMETHYLPYRIMIDIN-2-YL)-1,3,3A,4,6,6A-HEXAHYDROPYRROLO[3,4-C]PYRROL-5-YL]-[2-FLUORO-6-(TRIAZOL-2-YL)PHENYL]METHANONE Seltorexant | 1293281-49-8 | 5mg | 997元 |
| 2026/03/03 | S3503 | [2-(4,6-DIMETHYLPYRIMIDIN-2-YL)-1,3,3A,4,6,6A-HEXAHYDROPYRROLO[3,4-C]PYRROL-5-YL]-[2-FLUORO-6-(TRIAZOL-2-YL)PHENYL]METHANONE Seltorexant | 1293281-49-8 | 25mg | 2397元 |
| 2026/03/03 | S3503 | JNJ-42847922 Seltorexant | 1293281-49-8 | 100mg | 6970元 |