1309560-49-3
中文名稱(chēng)
度魯特韋SR異構(gòu)體
英文名稱(chēng)
Dolutegravir SR Isomer
CAS
1309560-49-3
分子式
C20H19F2N3O5
分子量
419.38
MOL 文件
1309560-49-3.mol
更新日期
2025/09/15 14:14:41
1309560-49-3 結(jié)構(gòu)式
基本信息
中文別名
多替拉韋雜質(zhì)5度魯特韋雜質(zhì)A
杜魯特韋雜質(zhì)6
多替拉韋雜質(zhì)13
度魯特韋雜質(zhì)41
度魯特韋對(duì)映異構(gòu)體
度魯特韋SR異構(gòu)體
多替拉韋SR異構(gòu)體
DOLUTEGRAVIR雜質(zhì)A
英文別名
Dolutegravir SR IsomerDoultegravirr SR Isomer
Dolutegravir Impurity 41
IMpurity of Dolutegravir
Dolutegravir (S,R)-lsomer
(4S,12aR)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4S,12aR)-
Dolutegravir impurity 6/Dolutegravir SR Isomer/(4S,12aR)-N-(2,4-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
所屬類(lèi)別
分析化學(xué)：藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品應(yīng)用領(lǐng)域
用途一
Dolutegravir SR Isomer is an isomeric derivative of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector. Dolutegravir SR Isomer.