131359-24-5
中文名稱(chēng)
131359-24-5
英文名稱(chēng)
(E,E)-Bis(2-hydroxybenzylidene)acetone
(2-HBA)
CAS
131359-24-5
分子式
C17H14O3
分子量
266.29
MOL 文件
131359-24-5.mol
更新日期
2026/02/12 14:22:50
131359-24-5 結(jié)構(gòu)式
基本信息
中文別名
2-HBA8化合物2-HBA
(E,E)-二(2-羥基芐亞基)丙酮
英文別名
HBB22-HBA
2-HBA Exclusive
bis(2-hydroxybenzylidene)acetone
(E,E)-Bis(2-hydroxybenzylidene)acetone
(E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA)
(E,E)-Bis(2-hydroxybenzylidene)acetone\n(2-HBA)
(1E,4E)-1,5-Bis(2-Hydroxyphenyl)-1,4-pentadien-3-one
1,4-Pentadien-3-one, 1,5-bis(2-hydroxyphenyl)-, (1E,4E)-
物理化學(xué)性質(zhì)
熔點(diǎn)>300 °C
沸點(diǎn)495.543±40.00 °C(Press: 760.00 Torr)(predicted)
密度1.270±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
儲(chǔ)存條件Sealed in dry,Store in freezer, under -20°C
溶解度在DMSO中的溶解度為15mg/mL（澄清溶液）
酸度系數(shù)(pKa)8.854±0.35(predicted)
形態(tài)粉末
顏色白色至米色
InChIKeyYNVAHBUBGBLIEY-WGDLNXRISA-N
131359-24-5價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-103667 | 131359-24-5 2-HBA | 131359-24-5 | 5mg | 360元 |
| 2026/06/05 | HY-103667 | 131359-24-5 2-HBA | 131359-24-5 | 10mM * 1mLin DMSO | 396元 |
| 2026/06/05 | HY-103667 | 131359-24-5 2-HBA | 131359-24-5 | 10mg | 540元 |
常見(jiàn)問(wèn)題列表
生物活性
2-HBA 是一個(gè)有效的 NAD(P)H: 醌受體氧化還原酶 1 (NQO1) 誘導(dǎo)劑，也可以激活半胱天冬酶-3 (caspase-3) 和半胱天冬酶-10 (caspase-10)。靶點(diǎn)
|
Caspase-3
|
Caspase-10
|
體外研究
When L1210 cells are exposed to 0.6 μM 2-HBA (bis(2-hydroxy-benzylidene)acetone), the specific activities of NQO1 and glutathione reductase increase by 6- and 1.5-fold, respectively. The total cellular glutathione content is also coordinately induced by 2.4-fold. In a more detailed study it is found that NQO1 is induced by 2-HBA in a concentration-dependent manner. Treatments with 2-HBA cause cell cycle arrest and apoptosis in both L1210 wild type cells and their Y8 drug-resistant counterparts in a concentration-dependent manner. 2-HBA can also activate caspase-3 and caspase-10.