1333210-07-3

中文名稱 1333210-07-3

英文名稱 Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro-

CAS 1333210-07-3

分子式 C21H22ClN3O

分子量 367.87

MOL 文件 1333210-07-3.mol

更新日期 2026/01/21 10:31:58

1333210-07-3 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 1333210-07-3價(jià)格(試劑級) 常見問題列表

基本信息

中文別名

SAR7334游離態(tài)

英文別名

SAR7334
TRCP6-IN-1
TRCP6 inhibitor
4-(((1R,2R)-2-((R)-3-Aminopiperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)oxy)-3-chlorobenzonitrile
Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro-

所屬類別

生物化工：激動劑抑制劑

物理化學(xué)性質(zhì)

沸點(diǎn)534.6±50.0 °C(Predicted)

密度1.30±0.1 g/cm3(Predicted)

儲存條件-20°C儲存

溶解度insoluble in H2O; ≥106.4 mg/mL in EtOH; ≥125.4 mg/mL in DMSO

酸度系數(shù)(pKa)10.95±0.20(Predicted)

形態(tài)Solid

顏色Light yellow to yellow

InChIKeyRLKRLNQEXBPQGQ-OZOXKJRCSA-N

SMILESClc1c(ccc(c1)C#N)O[C@H]2[C@@H](Cc4c2cccc4)N3C[C@@H](CCC3)N

安全數(shù)據(jù)

危險(xiǎn)性符號(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險(xiǎn)性描述H302-H315-H319-H335

防范說明P261-P305+P351+P338

WGK GermanyWGK 3

存儲類別11 - Combustible Solids

圖譜信息

1333210-07-3(1333210-07-3)核磁圖(¹HNMR)

1333210-07-3價(jià)格(試劑級)

報(bào)價(jià)日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價(jià)格
2026/07/06	S6634	1333210-07-3 SAR7334	1333210-07-3	5mg	2170.24元
2026/07/06	S6634	1333210-07-3 SAR7334	1333210-07-3	25mg	5170.37元
2026/06/05	HY-15699	SAR7334	1333210-07-3	1 mg	909元

常見問題列表

生物活性

SAR7334是一種新型，高效且可生物利用的TRPC6通道抑制劑。SAR7334在膜片鉗實(shí)驗(yàn)中阻斷了TRPC6電流，IC50為7.9 nM。

靶點(diǎn)

Target	Value
TPRC6 (Cell-free assay)	7.9nM

體外研究

SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca ²⁺ influx into cells with IC ₅₀ s of 9.5, 282 and 226?nM, whereas TRPC4 and TRPC5-mediated Ca ²⁺ entry is not affected. SAR7334 (1?μM) results in a major block of the Ang II-evoked calcium influx in the podocytes. SAR7334 (1 μM) has negligible effect on SOCE. SAR7334 dose-dependently reduces TRPC6 currents with an IC ₅₀ of 7.9?nM. SAR7334 (100?nM) substantially reduces TRPC6 currents.

體內(nèi)研究

SAR7334 (10?mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR).