133406-29-8

中文名稱 133406-29-8

英文名稱 ST034307

CAS 133406-29-8

分子式 C10H4Cl4O2

分子量 297.95

MOL 文件 133406-29-8.mol

更新日期 2023/03/20 15:41:27

133406-29-8 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 133406-29-8價(jià)格(試劑級(jí)) 常見問題列表

基本信息

中文別名

化合物ST034307
6-氯-2-(三氯甲基)-4H-苯并吡喃-4-酮

英文別名

ST034307
ST034307 >=98% (HPLC)
ST034307
ST-034307
ST 034307
6-chloro-2-(trichloromethyl)-4H-chromen-4-one
6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 6-chloro-2-(trichloromethyl)-

物理化學(xué)性質(zhì)

沸點(diǎn)329.1±42.0 °C(Predicted)

密度1.674±0.06 g/cm3(Predicted)

儲(chǔ)存條件Sealed in dry,Store in freezer, under -20°C

溶解度可溶于 DMSO（高達(dá) 30 mg/ml）或乙醇（高達(dá) 6 mg/ml）

形態(tài)固體

顏色黃色

穩(wěn)定性Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

InChI1S/C10H4Cl4O2/c11-5-1-2-8-6(3-5)7(15)4-9(16-8)10(12,13)14/h1-4H

InChIKeyNTDHYMSVCBGQJF-UHFFFAOYSA-N

SMILESClC(Cl)(Cl)C1=CC(C2=CC(Cl)=CC=C2O1)=O

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險(xiǎn)性描述H302

防范說明P280-P305+P351+P338

WGK GermanyWGK 3

存儲(chǔ)類別11 - Combustible Solids

圖譜信息

133406-29-8(133406-29-8)核磁圖(¹HNMR)

133406-29-8價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-101279	133406-29-8 ST034307	133406-29-8	5mg	770元
2026/06/05	HY-101279	133406-29-8 ST034307	133406-29-8	10mM * 1mLin DMSO	847元
2026/06/05	HY-101279	133406-29-8 ST034307	133406-29-8	10mg	1200元

常見問題列表

生物活性

ST034307 是一種有效的，選擇性的 adenylyl cyclase 1 抑制劑，IC50 值為 2.3 μM。

靶點(diǎn)

IC50: 2.3 μM (AC1)

體外研究

ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent. ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2. ST034307 significantly inhibits the forskolin- or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1. In contrast, ST034307 has no significant effects in the wild-type HEK cells. ST034307 significantly inhibits the Ca ²⁺ /calmodulin-stimulated cAMP accumulation in the hippocampal homogenates. ST034307 dose-dependently inhibits both the development and the maintenance of MOR-mediated sensitization of AC1.

體內(nèi)研究

ST034307 (0.25 μg) causes a significant relief of CFA-induced inflammatory pain in mice. ST034307 exhibits an estimated median effective dose (E ₅₀ ) value for analgesia of 0.28 μg in the mouse pain model.