1334921-03-7
中文名稱(chēng)
TAI-1
英文名稱(chēng)
TAI-1
CAS
1334921-03-7
分子式
C24H21N3O3S
分子量
431.51
MOL 文件
1334921-03-7.mol
更新日期
2023/09/21 18:03:26
1334921-03-7 結(jié)構(gòu)式
基本信息
中文別名
化合物TAI1 英文別名
TAI 1TAI1
TAI-1 USP/EP/BP
TAI 1,TAI1,inhibit,Inhibitor,Apoptosis,TAI-1
N-(4-(4-(4-methoxyphenoxy)-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide
4-Pyridinecarboxamide, N-[4-[4-(4-methoxyphenoxy)-2,6-dimethylphenyl]-2-thiazolyl]-
所屬類(lèi)別
生物化工：Microtubule Associated 抑制劑物理化學(xué)性質(zhì)
密度1.281±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度≥43.2 mg/mL in DMSO; insoluble in H2O; ≥3.17 mg/mL in EtOH
酸度系數(shù)(pKa)5.38±0.70(Predicted)
形態(tài)固體
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
TAI-1是一個(gè)有效的特異Hec1抑制劑，會(huì)打亂Hec1-Nek2蛋白質(zhì)相互作用。體外研究
TAI-1 disrupts the binding of Nek2 to Hec1, which leads to degradation of Nek2 and chromosomal misalignment. TAI-1 shows strong growth inhibitory potency at nM levels across a broad spectrum of tumor cells, and produces synergistic activity with doxorubicin, topotecan and paclitaxel in leukemia, breast and liver cancer cells.體內(nèi)研究
TAI-1 (20 mg/kg i.v. or 150 mg/kg p.o.) causes significant tumor growth delay in Huh-7 model and modest tumor inhibition in Colo205 and MDA-MB-231 models.