13419-46-0
中文名稱
S-[(1E)-1;2-DICHLOROETHENYL]--L-CYSTEINE
英文名稱
S-(E-1,2-DICHLOROVINYL)-L-CYSTEINE
CAS
13419-46-0
分子式
C5H7Cl2NO2S
分子量
216.09
MOL 文件
13419-46-0.mol
13419-46-0 結(jié)構(gòu)式
基本信息
中文別名
S-(E-1,2-二氯乙烯基)-L-半胱氨酸 英文別名
S-[(1E)-1DCVC (E-isomer)
2-dichloroethenyl]--L-cysteine
S-[(1E)-1
2-DICHLOROETHENYL]--L-CYSTEINE
L-Cysteine, S-[(1E)-1,2-dichloroethenyl]-
DCVC (S-[(1E)-1,2-dichloroethenyl]--L-cysteine)
2-amino-3-[(E)-1,2-dichloroethenyl]sulfanylpropanoic acid
物理化學(xué)性質(zhì)
熔點(diǎn)155-156 °C (decomp)
沸點(diǎn)339.7±42.0 °C(Predicted)
密度1.437 (estimate)
折射率1.6100 (estimate)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : 23 mg/mL (106.44 mM);Water : 1.034 mg/mL (4.79 mM)
酸度系數(shù)(pKa)2.01±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
DCVC (S-[(1E)-1,2-dichloroethenyl]--L-cysteine) 是一種三氯乙烯 (TCE) 的生物活性代謝產(chǎn)物。DCVC 可抑制病原體刺激的組織培養(yǎng)物中促炎細(xì)胞因子 IL-1β，IL-8 和 TNF-α 的釋放。體外研究
Extraplacental membranes are cultured for 4, 8, and 24h with the trichloroethylene (TCE) metabolite S-(1,2-dichlorovinyl)-l-cysteine (DCVC) in the absence or presence of lipoteichoic acid (LTA) or lipopolysaccharide (LPS) to simulate infection. In addition, membranes were cocultured with DCVC and Group B Streptococcus (GBS). DCVC (5-50μM) significantly inhibited LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4h. DCVC inhibits pathogen-stimulated cytokine (IL-1β, IL-8, and TNF-α) release in a concentration-dependent manner.