1361224-53-4

中文名稱(chēng) AMG-3969

英文名稱(chēng) AMG-3969

CAS 1361224-53-4

更新日期 2026/06/01 10:25:42

分子式 C21H20F6N4O3S

分子量 522.46

MOL 文件 1361224-53-4.mol

1361224-53-4 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 AMG-3969價(jià)格(試劑級(jí)) 常見(jiàn)問(wèn)題列表

基本信息

中文別名

化合物AMG-3969
AMG-3969游離態(tài)
4-[(2S)-4-[(6-氨基-3-吡啶基)磺?；鵠-2-(1-丙炔-1-基)-1-哌嗪基]-Α,Α-雙(三氟甲基)-苯甲醇
(S)-2-(4-(4-((6-氨基吡啶-3-基)磺?；?-2-(丙-1-炔-1-基)哌嗪-1-基)苯基)-1,1,1,3,3-六氟丙烷-2-醇

英文別名

AMG-3969

所屬類(lèi)別

生物化工：激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

沸點(diǎn)648.8±65.0 °C(Predicted)

密度1.56±0.1 g/cm3(Predicted)

儲(chǔ)存條件2-8°C(protect from light)

溶解度DMSO:100.0(Max Conc. mg/mL);191.4(Max Conc. mM)

酸度系數(shù)(pKa)10.12±0.15(Predicted)

形態(tài)Solid

顏色White to off-white

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險(xiǎn)性描述H302-H315-H319-H335

防范說(shuō)明P261-P305+P351+P338

海關(guān)編碼2935909099

圖譜信息

AMG-3969(1361224-53-4)核磁圖(¹HNMR)

AMG-3969價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱(chēng)	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-12411	AMG-3969 AMG-3969	1361224-53-4	1mg	993元
2026/06/05	HY-12411	AMG-3969 AMG-3969	1361224-53-4	5mg	2320元
2026/06/05	HY-12411	AMG-3969 AMG-3969	1361224-53-4	10mM * 1mLin DMSO	2667元

常見(jiàn)問(wèn)題列表

生物活性

AMG-3969是有效的葡萄糖激酶-葡糖激酶調(diào)節(jié)蛋白(GK-GKRP)相互作用的干擾物，IC50值為4 nM。

靶點(diǎn)

IC50: 4 nM (GK-GKRP)

體外研究

AMG-3969 exhibits potent cellular activity with an EC ₅₀ of 0.202 μM and IC ₅₀ of 4 nM, . It potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation in vitro (isolated hepatocytes).

體內(nèi)研究

AMG-3969 has good in vivo pharmacokinetic (PK) properties in rats (75%) and significantly lowers blood glucose levels in a dose-dependent manner db/db mice. AMG-3969 (100 mg/kg) demonstrates significant reductions in blood glucose with robust efficacy (56% reduction) observed at the 8 h time point. AMG-3969 demonstrates dose-dependent efficacy in three models of diabetes: diet induced obese (DIO), ob/ob and db/db mice; however,AMG-3969 is ineffective in lowering blood glucose in normoglycaemic C57BL/6 (B6) mice. AMG-3969 is highly effective in promoting carbohydrate substrate. AMG-3969 exhibits extended changes to carbohydrate oxidation as observed by increased respiratory exchange ratio into the next night and day after a single dose.