1373232-26-8

中文名稱 N-[(1S)-1-(氨基羰基)-4 -[(2 - 氯-1-亞氨基乙基氨基]丁基]-苯甲酰胺鹽酸鹽

英文名稱 N-[(1S)-1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide hydrochloride

CAS 1373232-26-8

分子式 C14H20Cl2N4O2

分子量 347.24

MOL 文件 1373232-26-8.mol

更新日期 2024/02/17 22:12:45

1373232-26-8 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 N-[(1S)-1-(氨基羰基)-4 -[(2 - 氯-1-亞氨基乙基氨基]丁基]-苯甲酰胺鹽酸鹽價格(試劑級) 常見問題列表

基本信息

中文別名

N-[(1S)-1-(氨基羰基)-4 -[(2 - 氯-1-亞氨基乙基氨基]丁基]-苯甲酰胺鹽酸鹽

英文別名

Cl-Amidine (hydrochloride)
N-[(1S)-1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide hydrochloride
Cl-Amidine (hydrochloride) - Sold under license from the University of South Carolina under U.S. Patent No. 7,964,363

所屬類別

有機原料：羧酸類化合物及衍生物

物理化學(xué)性質(zhì)

儲存條件-20°C儲存

溶解度DMF: 14 mg/ml; DMSO: 50 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 3 mg/ml

形態(tài)結(jié)晶固體

顏色White to light yellow

安全數(shù)據(jù)

危險性符號(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險性描述H315-H319-H335-H302

防范說明P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

圖譜信息

N-[(1S)-1-(氨基羰基)-4 -[(2 - 氯-1-亞氨基乙基氨基]丁基]-苯甲酰胺鹽酸鹽(1373232-26-8)核磁圖(¹HNMR)

N-[(1S)-1-(氨基羰基)-4 -[(2 - 氯-1-亞氨基乙基氨基]丁基]-苯甲酰胺鹽酸鹽價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-100574A	N-[(1S)-1-(氨基羰基)-4 -[(2 - 氯-1-亞氨基乙基氨基]丁基]-苯甲酰胺鹽酸鹽 Cl-amidine hydrochloride	1373232-26-8	1 mg	502元
2026/06/05	HY-100574A	N-[(1S)-1-(氨基羰基)-4 -[(2 - 氯-1-亞氨基乙基氨基]丁基]-苯甲酰胺鹽酸鹽 Cl-amidine hydrochloride	1373232-26-8	5mg	1200元
2026/06/05	HY-100574A	N-[(1S)-1-(氨基羰基)-4 -[(2 - 氯-1-亞氨基乙基氨基]丁基]-苯甲酰胺鹽酸鹽 Cl-amidine hydrochloride	1373232-26-8	10mM * 1mLin DMSO	1320元

常見問題列表

生物活性

Cl-amidine hydrochloride 是口服有效的 PAD 抑制劑，其對 PAD1、PAD3 和 PAD4 的 IC50 值分別為0.8 μM、 6.2 μM 和 5.9 μM。Cl-amidine hydrochloride 可誘導(dǎo)癌細(xì)胞的凋亡。Cl-amidine hydrochloride 可誘導(dǎo) miR-16，引起細(xì)胞周期阻滯。Cl-Amidine hydrochloride 可阻斷組蛋白 3 瓜氨酸化和中性粒細(xì)胞胞外陷阱的形成，并提高敗血癥小鼠的存活率。

靶點

IC50: 0.8 μM (PAD1), 5.9 μM (PAD4), 6.2 μM (PAD3).

體外研究

Cl-amidine is a bioavailable haloacetamidine-based compound that inhibits all the active PAD isozymes with near equal potency (k _inact /K _I =13,000 M _-1 ?min-1 for PAD4).
Cl-amidine (0, 5, 10, 15, 20, 25, 50 μg/mL, 24 hours) induces apoptosis in TK6 lymphoblastoid cells and HT29 colon cancer cells in a dose-dependent manner. Interestingly, the colon cancer cell line (HT29) is relatively resistant to apoptosis caused by Cl-amidine.
Cl-Amidine prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model.

Apoptosis Analysis.

Cell Line:	TK6 lymphoblastoid cells and HT29 colon cancer cells.
Concentration:	0, 5, 10, 15, 20, 25, 50 μg/mL.
Incubation Time:	24 h.
Result:	Induced apoptosis dose-dependently.

體內(nèi)研究

Cl-amidine (75 mg/kg, ip once daily) suppresses and treats DSS-induced colitis in mice.
Cl-amidine (5, 25, 75 mg/kg, oral gavage, once daily) leads to significant reductions in the histology scores dose-dependently.

Animal Model:	C57BL/6 mice (8-12 wk old, DSS mouse model of colitis).
Dosage:	75 mg/kg.
Administration:	IP once daily.
Result:	Suppressed PAD activity, protein citrullination, and PAD levels in the colon in vivo.

Animal Model:	C57BL/6 mice (8-12 wk old, DSS mouse model of colitis).
Dosage:	5, 25, 75 mg/kg.
Administration:	Oral gavage once daily.
Result:	Led to significant reductions in the histology scores.