1380672-07-0

中文名稱 G007-LK

英文名稱 G007-LK

CAS 1380672-07-0

分子式 C25H16ClN7O3S

分子量 529.96

MOL 文件 1380672-07-0.mol

更新日期 2026/06/02 18:15:52

1380672-07-0 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 G007-LK價格(試劑級) 常見問題列表

基本信息

中文別名

G007-LK游離態(tài)
TANKYRASE抑制劑(G007-LK)
4-[5-[(1E)-2-[4-(2-氯苯基)-5-[5-(甲基磺?；?-2-吡啶基]-4H-1,2,4-三唑-3-基]乙烯基]-1,3,4-惡二唑-2-基]苯甲腈

英文別名

G007-LK
CS-1659
G007 LK
G007LK
G007-LK
G007 LK
G007LK
Tankyrase 1/2 Inhibitor VI, G007-LK - Calbiochem
(E)-4-(5-(2-(4-(2-chlorophenyl)-5-(5-(methylsulfonyl)pyridin-2-yl)-4H-1,2,4-triazol-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)benzonitrile
4-[5-[(1E)-2-[4-(2-Chlorophenyl)-5-[5-(methylsulfonyl)-2-pyridinyl]-4H-1,2,4-triazol-3-yl]ethenyl]-1,3,4-oxadiazol-2-yl]benzonitrile
Benzonitrile, 4-[5-[(1E)-2-[4-(2-chlorophenyl)-5-[5-(methylsulfonyl)-2-pyridinyl]-4H-1,2,4-triazol-3-yl]ethenyl]-1,3,4-oxadiazol-2-yl]-

所屬類別

生物化工：激動劑抑制劑

物理化學(xué)性質(zhì)

沸點817.3±75.0 °C(Predicted)

密度1.47±0.1 g/cm3(Predicted)

儲存條件+2C to +8C

溶解度≥26.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH

酸度系數(shù)(pKa)-1.68±0.10(Predicted)

形態(tài)白色粉末

顏色Off-white to yellow

InChI1S/C25H16ClN7O3S/c1-37(34,35)18-10-11-20(28-15-18)24-31-29-22(33(24)21-5-3-2-4-19(21)26)12-13-23-30-32-25(36-23)17-8-6-16(14-27)7-9-17/h2-13,15H,1H3/b13-12+

InChIKeyHIWVLHPKZNBSBE-OUKQBFOZSA-N

SMILES[S](=O)(=O)(C)c1cnc(cc1)c2[n](c(nn2)\C=C\c4nnc([o]4)c5ccc(cc5)C#N)c3c(cccc3)Cl

安全數(shù)據(jù)

危險性符號(GHS) 有毒 (GHS06)

GHS06

警示詞危險

危險性描述H301

防范說明P301+P310

WGK GermanyWGK 2

存儲類別11 - Combustible Solids

圖譜信息

G007-LK(1380672-07-0)核磁圖(¹HNMR)

G007-LK價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-12438	G007-LK G007-LK	1380672-07-0	5mg	1200元
2026/06/05	HY-12438	G007-LK G007-LK	1380672-07-0	10 mM * 1 mLin DMSO	1399元
2026/06/05	HY-12438	G007-LK G007-LK	1380672-07-0	10mg	2000元

常見問題列表

生物活性

G007-LK是一種有效的選擇性tankyrase抑制劑，對TNKS1/2的IC50分別為46 nM 和 25 nM。

靶點

Target	Value
TNKS2 (Cell-free assay)	25 nM
TNKS1 (Cell-free assay)	46 nM

體外研究

G007-LK is a potent inhibitor of TNKS1 and TNKS2, with IC ₅₀ s of 46 nM and 25 nM, respectively, and a cellular IC ₅₀ of 50 nM. G007-LK shows no inhibition of PARP1 at doses up to 20 μM, and has a high CYP3A4 inhibition IC ₅₀ value (>25 μM). G007-LK (0-20 μM) dose-dependently inhibits hepatocellular carcinoma (HCC) cell growth. G007-LK also downregulates the levels of YAP by upregulating AMOTL1 and AMOTL2 in HCC cell lines. In addition, G007-LK (0-20 μM) synergizes with MEK and AKT inhibitors to suppress HCC cell proliferation.

體內(nèi)研究

G007-LK displays great pharmacokinetic profile in ICR mice. G007-LK (100 mg/kg chow, p.o.) significantly reduces lineage tracing from LGR5 ⁺ intestinal stem cells in mice. G007-LK (100 mg/kg chow, p.o.) specifically targets LGR5 ⁺ WNT-dependent intestinal stem cells in Lgr5-EGFP-CreERT2;R26R-tdTomato mice. G007-LK (10, 50 mg/kg, p.o.) also suppressses canonical WNT signalling. Furthermore, G007-LK (100, 1000 mg/kg chow, p.o) shows no effect on the alteration of duodenal morphology.