139290-65-6

中文名稱(chēng) 139290-65-6

英文名稱(chēng) (R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL

CAS 139290-65-6

分子式 C22H28FNO3

分子量 373.46

MOL 文件 139290-65-6.mol

更新日期 2026/05/25 13:08:20

139290-65-6 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 139290-65-6價(jià)格(試劑級(jí)) 常見(jiàn)問(wèn)題列表

基本信息

中文別名

氟利色林
諾和靈 M100907
VOLINANSERIN MDL 100907 (R構(gòu)型)
Volinanserin MDL 100907 (R構(gòu)型）

英文別名

M 100907
MDL100907
R-MDL 100907
VOLINANSERIN
MDL 100907 NEW
MDL100907-L-tartrate
MDL100907 tartrate salt
MDL 100907 (MDL-100907
MDL-100907(Volinanserin)
Volinanserin (MDL100907)

物理化學(xué)性質(zhì)

熔點(diǎn)89-91°C

沸點(diǎn)499.4±45.0 °C(Predicted)

密度1.150±0.06 g/cm3(Predicted)

儲(chǔ)存條件-20°C冷凍

儲(chǔ)存條件2-8°C

溶解度二甲基亞砜：≥20mg/mL

酸度系數(shù)(pKa)13.93±0.20(Predicted)

形態(tài)粉末

顏色灰白色至淺棕色

InChI1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3/t21-/m1/s1

InChIKeyHXTGXYRHXAGCFP-OAQYLSRUSA-N

SMILESCOc1cccc([C@H](O)C2CCN(CC2)CCc3ccc(F)cc3)c1OC

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS) 環(huán)境危害 (GHS09)

GHS09

警示詞警告

危險(xiǎn)性描述H400

防范說(shuō)明P273

危險(xiǎn)品標(biāo)志N

危險(xiǎn)類(lèi)別碼50

安全說(shuō)明61

危險(xiǎn)品運(yùn)輸編號(hào)UN 3077 9 / PGIII

WGK Germany3

存儲(chǔ)類(lèi)別11 - Combustible Solids

圖譜信息

139290-65-6(139290-65-6)核磁圖(¹HNMR)

139290-65-6價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱(chēng)	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-14940	139290-65-6 Volinanserin	139290-65-6	5mg	1100元
2026/06/05	HY-14940	139290-65-6 Volinanserin	139290-65-6	10mM * 1mLin DMSO	1210元
2026/06/05	HY-14940	139290-65-6 Volinanserin	139290-65-6	10mg	1760元

常見(jiàn)問(wèn)題列表

生物活性

Volinanserin (Volinanserin Hydrochloride Salt, MDL100907, M 100907, MDL-100,907)是一種高度選擇性的、有效的 5-HT2 receptor 的拮抗劑，其Ki值為0.36 nM。Volananserin 具有治療精神紊亂的藥物活性。

靶點(diǎn)

Target	Value
5-HT2 receptor (Cell-free assay)	0.36 nM(Ki)

體外研究

Volinanserin (MDL 100907) is a potent antagonist at the 5-HT ₂ receptor, with a K _i of 0.36 nM, and shows 300-fold selectivity for 5-HT ₂ receptor over 5-HT _1c receptor, alpha-1 and DA D ₂ receptors. Volinanserin has antipsychotic activity.

體內(nèi)研究

Volinanserin (MDL 100907; 0.008-2.0 mg/kg, i.p.) significantly decreases d-amphetamine-stimulated locomotor activity in mice, with an ED ₅₀ of 0.3 mg/kg, but shows no obvious reduction in the base-line locomotor activity in mice. Volinanserin produces atalepsy with an ED ₅₀ of 10-50 mg/kg in rats. Volinanserin does not reduces apomorphine-induced stereotypies or produces catalepsy in rats. Volinanserin (M100907) combined with MK-801 significantly decreases reinforcers at 1 μg/kg, but dose-dependently (10, 100 μg/kg) antagonizes the disruptive effect of MK-801 in rats via i.p. administration. Volinanserin (6.25 μg/kg) enhances the antidepressant-like action of desipramine in rats performing under a DRL 72-s schedule, and elevates the antidepressant-like effect of tranylcypromine.