141064-23-5
141064-23-5 結(jié)構(gòu)式
基本信息
諾美林草酸鹽
呫諾美林草酸鹽
LY246708 oxalate
Xanomeline oxalate
Xanomeline oxalate salt
LY246708
MEMCOR
LUMERON
3-(3-Hexyloxy-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine oxalate
3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridineoxalate
3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridine ethanedioate (1:1)
物理化學(xué)性質(zhì)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-13410R | 諾美林草酸鹽 Xanomeline oxalate (Standard) | 141064-23-5 | 5 mg | 990元 |
| 2026/06/05 | HY-13410R | 諾美林草酸鹽 Xanomeline oxalate (Standard) | 141064-23-5 | 10 mg | 1580元 |
| 2026/06/05 | HY-13410R | 諾美林草酸鹽 Xanomeline oxalate (Standard) | 141064-23-5 | 25 mg | 2845元 |
常見問題列表
muscarinic receptor
Xanomeline stimulates phosphoinositide (PI) hydrolysis in the A9 L m1 cells.
Xanomeline inhibits [
3
H]-pirenzepine ([
3
H]-PZ) and [
3
H]-
oxotremorine
-M ([
3
H]-OXO-M) binding to rat brain with K
i
s of 7 and 3 nM, respectively.
Xanomeline robustly stimulates in vivo PI hydrolysis and the effect is blocked by muscarinic antagonists, demonstrating mediation by muscarinic receptors. In mice the ED 100 for Xanomeline-induced stimulation of [ 3 H]-IP accumulation is 54 μmole/kg in hippocampus. And in rats the ED 100 for Xanomeline-induced stimulation of [ 3 H]-IP accumulation is 8.1 μmole/kg in hippocampus.
| Animal Model: | Male CF1 mice weighing 18-20 g are injected [ 3 H]-myoinositol |
| Dosage: | 8.1-81 μmole/kg |
| Administration: | S.c. injections; 1 h prior to killing and 1 h after the administration |
| Result: | Increased accumulation in a dose-related manner up to 130%, 75%, 60% above lithium levels in hippocampus, cortex and neostriatum, respectively. And did not increase accumulation of [ 3 H]-IP in the brain stem. Induced salivation, tremor and hypothermia in mice with the ED 50 of 13.7±0.8 μmole/kg. |
| Animal Model: | Rats are injected [ 3 H]-myoinositol |
| Dosage: | 2.7-81 μmole/kg |
| Administration: | S.c. injections; 1 h prior to killing and 1 h after the administration |
| Result: | Increased [ 3 H]-IP formation dose dependently in hippocampus up to 221% above lithium control. |