1422269-30-4
中文名稱
(S)-3-(1H-吲哚-3-基)-N-((1-(4-甲氧基苯基)環(huán)己基)甲基)-2-(3-(4-硝基苯基)脲基)丙酰胺
英文名稱
ML 18
CAS
1422269-30-4
分子式
C32H35N5O5
分子量
569.66
MOL 文件
1422269-30-4.mol
更新日期
2026/07/13 11:29:13
1422269-30-4 結(jié)構(gòu)式
基本信息
中文別名
化合物ML 18 英文別名
ML 18ML18, >98%
BRS-3 antagonist
ML18
ML-18
ML 18
BRS-3 ANTAGONIST
1422269-30-4
(2S)-3-(1H-INDOL-3-YL)-N-{[1-(4-METHOXYPHENYL)CYCLOHEXYL]METHYL}-2-{[(4-NITROPHENYL)CARBAMOYL]AMINO}PROPANAMIDE
物理化學(xué)性質(zhì)
沸點821.8±65.0 °C(Predicted)
密度1.291±0.06 g/cm3(Predicted)
儲存條件Sealed in dry,2-8°C
溶解度可溶于DMSO
酸度系數(shù)(pKa)11.99±0.46(Predicted)
形態(tài)固體
顏色White to yellow
(S)-3-(1H-吲哚-3-基)-N-((1-(4-甲氧基苯基)環(huán)己基)甲基)-2-(3-(4-硝基苯基)脲基)丙酰胺價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/06/05 | HY-101844 | (S)-3-(1H-吲哚-3-基)-N-((1-(4-甲氧基苯基)環(huán)己基)甲基)-2-(3-(4-硝基苯基)脲基)丙酰胺 ML-18 | 1422269-30-4 | 1 mg | 329元 |
| 2026/06/05 | HY-101844 | (S)-3-(1H-吲哚-3-基)-N-((1-(4-甲氧基苯基)環(huán)己基)甲基)-2-(3-(4-硝基苯基)脲基)丙酰胺 ML-18 | 1422269-30-4 | 5mg | 663元 |
| 2026/06/05 | HY-101844 | (S)-3-(1H-吲哚-3-基)-N-((1-(4-甲氧基苯基)環(huán)己基)甲基)-2-(3-(4-硝基苯基)脲基)丙酰胺 ML-18 | 1422269-30-4 | 10mM * 1mLin DMSO | 831元 |
常見問題列表
生物活性
ML-18是一種抑制肺癌生長的非肽鈴蟾肽受體亞型-3 (BRS-3) 拮抗劑。靶點
IC50: 4.8 μM (BRS-3)
體外研究
ML-18 inhibits specific 125 I-BA1 (DTyr-Gln-Trp-Ala-Val-βAla-His-Phe-Nle-NH2)BB6-14 binding to NCI-H1299 lung cancer cells stably transfected with BRS-3 with IC 50 values of 4.8 μM. ML-18 binds with lower affinity to the GRPR and NMBR with IC 50 values of 16 and more than 100 μM, respectively. ML-18 at 16 μM inhibits the ability of 10 nM BA1 to elevate cytosolic Ca 2+ in a reversible manner using lung cancer cells loaded with FURA2-AM. ML-18 at 16 μM inhibits the ability of 100 nM BA1 to cause tyrosine phosphorylation of the EGFR and ERK in lung cancer cells. It inhibits the proliferation of lung cancer cells.