143557-91-9
143557-91-9 結(jié)構(gòu)式
基本信息
N-BOC-去甲基托丙醇
3-羥基-8-氮雜雙環(huán)[3.2.1]辛烷-8-甲酸叔丁酯
內(nèi)向-N-BOC-3-羥基-8-氮雜雙環(huán)[3.2.1]辛烷
內(nèi)向-8-BOC-3-羥基-8-氮雜雙環(huán)[3.2.1]辛烷
(3-內(nèi))-3-羥基-8-氮雜雙環(huán)[3.2.1]辛烷-8-甲酸叔丁酯
3-ENDO-3-羥基-8-氮雜雙環(huán)[3.2.1]辛烷-8-甲酸叔丁酯
N-tert-Butoxycarbonylnortropan-3-ol
endo-N-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane
endo-8-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane
(3-endo)-N-Boc-3-hydroxy-8-azabicyclo[3.2.1]octane
tert-butyl 3-endo-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
tert-Butyl 3-endo-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
tert-butyl (1R,3r,5S)-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
rel-tert-butyl (1R,3R,5S)-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
(3-endo)-3-Hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
24424-99-5
538-09-0
143557-91-9
以二碳酸二叔丁酯和內(nèi)-8-氮雜雙環(huán)[3.2.1]辛烷-3-醇為原料合成3-endo-3-羥基-8-氮雜雙環(huán)[3.2.1]辛烷-8-甲酸叔丁酯的一般步驟：將內(nèi)-8-氮雜雙環(huán)[3.2.1]辛-3-醇（3.6 g，28.3 mmol）溶于二氯甲烷（50 mL）中，并將溶液冷卻至0℃。在攪拌下，依次加入三乙胺（7.8 mL，56.7 mmol）和二碳酸二叔丁酯（7.4 g，33.9 mmol）。將反應(yīng)混合物逐漸升溫至室溫，并繼續(xù)攪拌12小時(shí)。反應(yīng)完成后，用蒸餾水稀釋反應(yīng)混合物。分離有機(jī)層，依次用飽和檸檬酸水溶液、蒸餾水和飽和食鹽水洗滌。有機(jī)層用無(wú)水硫酸鎂干燥，過(guò)濾后減壓濃縮，得到3-endo-3-羥基-8-氮雜雙環(huán)[3.2.1]辛烷-8-甲酸叔丁酯，為白色固體（6.45 g，28.4 mmol，產(chǎn)率100%）。質(zhì)譜（ESI）m/z：228 [M + H]+。
參考文獻(xiàn)：
[1] Patent: WO2007/63071, 2007, A1. Location in patent: Page/Page column 15
[2] Patent: US2007/123525, 2007, A1. Location in patent: Page/Page column 20
[3] Patent: WO2016/91776, 2016, A1. Location in patent: Page/Page column 210; 211
[4] Patent: WO2014/152144, 2014, A1. Location in patent: Paragraph 0190
[5] Patent: WO2009/106534, 2009, A1. Location in patent: Page/Page column 73
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | XW0214355791906 | 3-羥基-8-氮雜雙環(huán)[3.2.1]辛烷-8-甲酸叔丁酯 | 143557-91-9 | 100G | 1247元 |
| 2026/06/05 | XW0214355791905 | 3-羥基-8-氮雜雙環(huán)[3.2.1]辛烷-8-甲酸叔丁酯 | 143557-91-9 | 25G | 312元 |
| 2026/06/05 | XW0214355791904 | 3-羥基-8-氮雜雙環(huán)[3.2.1]辛烷-8-甲酸叔丁酯 | 143557-91-9 | 10G | 125元 |