1442684-77-6
中文名稱
AM2394
英文名稱
AM2394
CAS
1442684-77-6
分子式
C22H25N5O4
分子量
423.46
MOL 文件
1442684-77-6.mol
更新日期
2026/07/17 13:02:18
1442684-77-6 結(jié)構(gòu)式
基本信息
中文別名
化合物AM2394 英文別名
AM2394CS-2242
AM2394
AM 2394
N-[6'-(2-Hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methylurea
1-(6'-(2-hydroxy-2-methylpropoxy)-4-((5-methylpyridin-3-yl)oxy)-[3,3'-bipyridin]-6-yl)-3-methylurea
Urea, N-[6'-(2-hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methyl-
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)588.8±50.0 °C(Predicted)
密度1.266±0.06 g/cm3(Predicted)
儲(chǔ)存條件Inert atmosphere,Room Temperature
溶解度DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.50 mg/ml
酸度系數(shù)(pKa)12.66±0.70(Predicted)
形態(tài)結(jié)晶固體
顏色White to off-white
常見(jiàn)問(wèn)題列表
用途
AM 2394是一種結(jié)構(gòu)獨(dú)特的葡萄糖激酶激活劑(GKA)。AM-2394通過(guò)一個(gè)60 nM的EC50激活GK。生物活性
AM-2394 是一種新型的 glucokinase 激活劑 (GKA)。AM-2394激活葡萄糖激酶 (GK)，EC50 為 60 nM。靶點(diǎn)
EC50: 60 nM (glucokinase)
體內(nèi)研究
AM-2394, a structurally distinct glucokinase activator that displays a robust reduction in plasma glucose during an oral glucose tolerance test (OGTT) in ob/ob mice at a dose of 3 mg/kg. AM-2394 increases the affinity of glucokinase (GK) for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. AM-2394 exhibits good-to-moderate cross species plasma clearance, volume of distribution, and oral bioavailability, allowing for further evaluation in animal models.