144506-14-9
中文名稱
甘草查爾酮C
英文名稱
LICOCHALCONEC
CAS
144506-14-9
分子式
C21H22O4
分子量
338.4
MOL 文件
144506-14-9.mol
更新日期
2026/06/01 16:56:37
144506-14-9 結(jié)構(gòu)式
基本信息
中文別名
甘草查耳酮C甘草查而酮C
甘草查爾酮C
LICOCHALCONE C 甘草查爾酮C
英文別名
LICOCHALCONEC4,4'-Dihydroxy-2-Methoxy-3-prenylchalcone
(E)-3-[4-hydroxy-2-methoxy-3-(3-methylbut-2-enyl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
2-Propen-1-one,3-[4-hydroxy-2-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-1-(4-hydroxyphenyl)-,(2E)-
所屬類別
生物化工：提取物物理化學(xué)性質(zhì)
外觀性狀黃色結(jié)晶粉末，可溶于甲醇、乙醇、DMSO等有機(jī)溶劑，來源于甘草根莖。
沸點(diǎn)536.1±50.0 °C(Predicted)
密度1.181±0.06 g/cm3 (20 ºC 760 Torr)
儲存條件-20°C
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
酸度系數(shù)(pKa)7.82±0.15(Predicted)
形態(tài)粉末
顏色黃色
生物來源plant
主要應(yīng)用metabolomics
vitamins, nutraceuticals, and natural products
vitamins, nutraceuticals, and natural products
InChI1S/C21H22O4/c1-14(2)4-11-18-20(24)13-8-16(21(18)25-3)7-12-19(23)15-5-9-17(22)10-6-15/h4-10,12-13,22,24H,11H2,1-3H3/b12-7+
InChIKeyWBDNTJSRHDSPSR-KPKJPENVSA-N
SMILESO(C)c1c(c(ccc1\C=C\C(=O)c2ccc(cc2)O)O)CC=C(C)C
甘草查爾酮C價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2025/12/22 | HY-N0374 | 甘草查爾酮C Licochalcone C | 144506-14-9 | 1 mg | 1450元 |
| 2025/12/22 | HY-N0374 | 甘草查爾酮C Licochalcone C | 144506-14-9 | 5mg | 3500元 |
| 2025/12/22 | HY-N0374 | 甘草查爾酮C Licochalcone C | 144506-14-9 | 10mM * 1mLin DMSO | 3650元 |
常見問題列表
生物活性
Licochalcone C 能夠抑制 α-葡萄糖苷酶 (α-glucosidase)，其對 α-葡萄糖苷酶和蛋白酪氨酸磷酸酶 1B 的 IC50 值分別為 <100 nM 和 92.43 μM。靶點(diǎn)
IC50: <100 nM (α-glucosidase), 92.43 μM (PTP1B).
體外研究
Licochalcone C could inhibit α- glucosidase, with IC50s of <100 nM and 92.43 μM for α- glucosidase and PTP1B, respectively. It is also indicated that Licochalcone C induces T24 cell apoptosis in a concentration?dependent manner. Licochalcone C treatment reduces the levels of the anti?apoptotic mRNAs (Bcl-2, Bcl-w and Bcl-XL) and increases expression of the pro-apoptotic mRNAs (Bax and Bim). The Bcl-2 family inhibitor (ABT-737) reduces apoptosis induced by licochalcone C in T24 cells.