1448-36-8
1448-36-8 結(jié)構(gòu)式
基本信息
膽酸甲酯, 98+%
5-BETA-CHOLANIC ACID-3-ALPHA, 7-ALPHA, 12-ALPHA-TRIOL METHYL ESTER
CHOLIC ACID METHYL ESTER
METHYL 4-(3,7,12-TRIHYDROXY-10,13-DIMETHYLPERHYDROCYCLOPENTA[A]PHENANTHREN-17-YL)PENTANOATE
METHYL CHOLATE
Methyl 4-(3,7,12-trihydroxy-10,13-dimethylperhydrocyclopenta[a]phenanthren-17-yl)pen
CHOLIC ACID METHYL ESTER(P)
Methyl cholate, 98+%
3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid methyl ester
3α,7α,12α-Triol-5β-24-cholanoic acid methyl ester
Cholic acid methyl
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
67-56-1
81-25-4
1448-36-8
向膽酸(2.0g, 4.9mmol)的甲苯/甲醇(30ml, V/V=2:1)混合溶液中加入三甲基硅基重氮甲烷(3.67ml, 7.34mmol)，于20℃下攪拌反應(yīng)2小時(shí)。通過(guò)薄層色譜(TLC, 展開(kāi)劑比例為甲醇/二氯甲烷=1:10)監(jiān)測(cè)反應(yīng)進(jìn)程，確認(rèn)膽酸完全消耗并有新斑點(diǎn)生成。反應(yīng)完成后，將反應(yīng)混合物濃縮，得到(R)-甲基 4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-三羥基-10,13-二甲基十六氫-1H-環(huán)戊[a]菲蒽-17-基)戊酸酯(2.08g, 產(chǎn)率100%)，為白色泡沫狀固體。其氫核磁共振譜(400MHz, CDCl3)數(shù)據(jù)如下：δ 3.98(m, 1H, C12-H), 3.85(m, 1H, C7-H), 3.45(m, 1H, C3-H), 3.66(s, 3H, OCH3), 0.98(d, 3H, 21-Me), 0.89(s, 3H, 19-Me), 0.69(s, 3H, 18-Me)。
參考文獻(xiàn)：
[1] Drug Metabolism and Disposition, 2017, vol. 45, # 7, p. 721 - 733
[2] Patent: WO2009/146218, 2009, A2. Location in patent: Page/Page column 141
[3] Tetrahedron Letters, 2010, vol. 51, # 1, p. 93 - 95
[4] Steroids, 2010, vol. 75, # 10, p. 701 - 709
[5] Tetrahedron Letters, 2011, vol. 52, # 52, p. 7128 - 7131
知名試劑公司產(chǎn)品信息
Methyl cholate, 98+%(1448-36-8)
Methyl Cholate,>96.0%(GC)(1448-36-8)